caa a22 4500 445307765 CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1774-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1774-9 Matevosyan Naira Open Medical Institute, Salzburg, Austria aut Periodontal disease and perinatal outcomes [Elektronische Daten] [Naira Matevosyan] Purpose: To elucidate plausible associations between periodontal disease (PD) and pregnancy events through meta-analysis of original research published between 1998 and 2010. Methods: One hundred and twenty-five randomized, case-control, matched-cohort studies on pregnancy and postpartum specifics in women with PD are identified through PubMed, LILACS, and Cochrane Register. Meta-study is performed on a sample of 992 births allocated from studies of level I-II-1 evidence. An oral inflammation score (OIS) is composed from parameteric and observational components of maternal PD. Pearson arrival process is modeled for exchangeable correlations. Results: Women with preeclampsia and preterm birth have poor periodontal parameters in both, treatment and placebo groups (OR 1.94-2.9). In puerperae with severe periodontitis birth weight is negatively correlated with maternal probing depth (r=−0.368), and C-reactive protein (r=−0.416). Higher rates of tobacco use (RR 3.02), bacterial vaginosis (RR 2.7), clinical attachment level (OR 2.76), and fetal tyrosine kinase (OR 1.6) contribute in increased rates of preeclamsia (RR 1.68), and prematurity (RR 2.75). After adding confounders into the model OIS remains significantly associated with preterm birth (OR 2.3). Conclusions: Maternal PD has strong associations with preeclampsia and prematurity. Springer-Verlag, 2010 Periodontal disease nationallicence Oral pathogens nationallicence Preeclampsia nationallicence Preterm birth nationallicence Bacterial vaginosis nationallicence Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 675-686 0932-0067 283:4<675 2011 283 404 https://doi.org/10.1007/s00404-010-1774-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1774-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Matevosyan Naira Open Medical Institute, Salzburg, Austria aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 675-686 0932-0067 283:4<675 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer