caa a22 4500 445307803 CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1447-8 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1447-8 Association between tobacco use in pregnancy and placenta-associated syndromes: a population-based study [Elektronische Daten] [Muktar Aliyu, O'Neil Lynch, Ronee Wilson, Amina Alio, Sibylle Kristensen, Phillip Marty, Valerie Whiteman, Hamisu Salihu] Introduction: Cigarette smoking is an established risk factor for adverse perinatal outcomes. The purpose of this study is to examine the association between maternal smoking in pregnancy and the occurrence of placental-associated syndromes (PAS). Methods: We analyzed data from a population-based retrospective cohort of singleton deliveries that occurred in the state of Missouri from 1989 through 2005 (N=1,224,133). The main outcome was PAS, a composite outcome defined as the occurrence of placental abruption, placenta previa, preeclampsia, small for gestational age, preterm or stillbirth. We used logistic regression models to generate adjusted odd ratios and their 95 percent confidence intervals. Non-smoking gravidas served as the referent category. Results: The overall prevalence of prenatal smoking was 19.6%. Cigarette smoking in pregnancy was associated with the composite outcome of placental syndromes (odds ratio, 95% confidence interval=1.59, 1.57-1.60). This association showed a dose-response relationship, with the risk of PAS increasing with increased quantity of cigarettes smoked. Similar results were observed between smoking in pregnancy and independent risks for abruption, previa, SGA, stillbirth, and preterm delivery. Conclusion: Maternal smoking in pregnancy is a risk factor for the development of placenta-associated syndrome. Smoking cessation interventions in pregnancy should continue to be encouraged in all maternity care settings. Springer-Verlag, 2010 Maternal smoking nationallicence Placenta-associated syndrome nationallicence Singletons nationallicence Population-based study nationallicence Aliyu Muktar Department of Preventive Medicine, Institute for Global Health, Vanderbilt University, Nashville, TN, USA aut Lynch O'Neil Department of Mathematics, Minnesota State University, Moorhead, MN, USA aut Wilson Ronee Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut Alio Amina Department of Family and Community Health, University of South Florida, Tampa, FL, USA aut Kristensen Sibylle Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA aut Marty Phillip Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut Whiteman Valerie Division of Maternal-Fetal-Medicine, Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA aut Salihu Hamisu Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 729-734 0932-0067 283:4<729 2011 283 404 https://doi.org/10.1007/s00404-010-1447-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1447-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aliyu Muktar Department of Preventive Medicine, Institute for Global Health, Vanderbilt University, Nashville, TN, USA aut NATIONALLICENCE 700 1- Lynch O'Neil Department of Mathematics, Minnesota State University, Moorhead, MN, USA aut NATIONALLICENCE 700 1- Wilson Ronee Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Alio Amina Department of Family and Community Health, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 700 1- Kristensen Sibylle Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Marty Phillip Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Whiteman Valerie Division of Maternal-Fetal-Medicine, Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 700 1- Salihu Hamisu Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 729-734 0932-0067 283:4<729 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer