caa a22 4500 445307811 CHVBK 20180317142618.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1481-6 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1481-6 Microdochectomy in the management of pathologic nipple discharge [Elektronische Daten] [Josip Fajdić, Nikola Gotovac, Zeljko Glavić, Zlatko Hrgović, Walter Jonat, Christian Schem] Background: There is a debate in the literature whether a pathologic nipple discharge is a distinct sign of breast carcinoma. Our own results obtained by the use of microdochectomy as a minimally invasive operative procedure in 184 patients with pathologic nipple discharge were analysed. The aim of this retrospective 20-year study was to assess the efficacy of microdochectomy in detecting early stages of intraductal breast carcinoma. Patients and methods: The study included data on 184 patients aged 24-77years (median 46.6) divided into two groups of premenopausal (n=123) and postmenopausal (n=61) women. There were 139 patients with unilateral single-duct sanguinolent discharge and 45 patients with other types of nipple discharge. The operative procedure consisted of the discharging duct excision by use of a guide probe, preceded by cytology and ductography studies. Results: Histopathology of the excised ducts revealed only three carcinomas in premenopausal women and ten carcinomas in postmenopausal women. In a total of 13 carcinomas, there were 4 ductal carcinomas in situ, detected in patients aged 41-72 (median 66) years. Twelve carcinomas were associated with sanguinolent nipple discharge. Papilloma was the most common histology finding (56.5%). Conclusion: Results of the study suggested mainly the association of sanguinolent single-duct nipple discharge and papilloma, whereas the rate of malignancies detected (7.0%) was consistent with literature reports. Microdochectomy proved to be a highly efficient operative method free from any impairment of the breast integrity. Conservative treatment with close clinical monitoring of the patient with cytology and ultrasonographic assessment might be possible in selected cases. Springer-Verlag, 2010 Breast nationallicence Pathologic discharge nationallicence Carcinoma nationallicence Microdochectomy nationallicence Fajdić Josip Department of Surgery, County Hospital Pozega, Pozega, Croatia aut Gotovac Nikola Department of Radiology, County Hospital Pozega, Pozega, Croatia aut Glavić Zeljko Department of Obstetrics and Gynecology, Osijek University Hospital, Osijek, Croatia aut Hrgović Zlatko Department of Obstetrics and Gynecology, Osijek University Hospital, Osijek, Croatia aut Jonat Walter Department of Obstetrics and Gynecology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany aut Schem Christian Department of Obstetrics and Gynecology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 851-854 0932-0067 283:4<851 2011 283 404 https://doi.org/10.1007/s00404-010-1481-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1481-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fajdić Josip Department of Surgery, County Hospital Pozega, Pozega, Croatia aut NATIONALLICENCE 700 1- Gotovac Nikola Department of Radiology, County Hospital Pozega, Pozega, Croatia aut NATIONALLICENCE 700 1- Glavić Zeljko Department of Obstetrics and Gynecology, Osijek University Hospital, Osijek, Croatia aut NATIONALLICENCE 700 1- Hrgović Zlatko Department of Obstetrics and Gynecology, Osijek University Hospital, Osijek, Croatia aut NATIONALLICENCE 700 1- Jonat Walter Department of Obstetrics and Gynecology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany aut NATIONALLICENCE 700 1- Schem Christian Department of Obstetrics and Gynecology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 851-854 0932-0067 283:4<851 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer