caa a22 4500 445307846 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1448-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1448-7 Factors affecting the latency period in patients with preterm premature rupture of membranes [Elektronische Daten] [Gidon Test, Amalia Levy, Arnon Wiznitzer, Moshe Mazor, Gershon Holcberg, Alexander Zlotnik, Eyal Sheiner] Objective: The objective of the study was to assess the factors affecting the latency period in woman with preterm premature rupture of membranes (PPROM) and evaluate morbidity associated with prolonged latency. Study design: A population-based retrospective study including all women with PPROM (prior to 37weeks' gestation) during the years 1998-2008 was conducted. Comparison of the latency period was conducted by the Mann-Whitney U test since the latency period was not normally distributed (most delivered in 24h). Multivariable logistic regression model was constructed to find independent factors associated with prolonged latency period (>72h). Results: During the study period, there were 1,399 singleton deliveries of patients with PPROM; 24.6% (345) occurred prior to 34weeks' gestation. The duration of the latency period was significantly longer among woman with PPROM before 34weeks as compared to PPROM after 34weeks' gestation (5.78 vs. 2.02days; p<0.001). Other factors associated with longer latency period were multiparity (more than one previous delivery) and maternal age >35. Using a multivariable analysis, the following factors were significantly associated with latency period >72h: lower gestational age (weeks, OR=0.8, 95% CI 0.77-0.84; p<0.001) and multiparity (OR=1.7, 95% CI 1.3-2.2; p<0.001). Prolonged latency period (>72h) was significantly associated with chorioamnionitis (OR=2.095, 95% CI 1.44-3.04; p<0.001) and oligohydramnios (OR=3.041, 95% CI 1.43-6.45; p=0.004) but not with placental abruption (OR=0.854, 95% CI 0.41-1.78; p=0.674) or perinatal mortality (OR=1.2, 95% CI 0.6-2.2; p=0.556). Conclusion: The duration of the latency period is inversely associated with gestational age. Nulliparity is associated with lower latency period. Prolonged latency is a significant risk factor for chorioamnionitis. Springer-Verlag, 2010 PPROM nationallicence Latency period nationallicence Gestational age nationallicence Nulliparity nationallicence Test Gidon The Joyce and Irving Goldman Medical School, Beersheba, Israel aut Levy Amalia Department of Epidemiology and Health Services Evaluation, Soroka University Medical Center, Beersheba, Israel aut Wiznitzer Arnon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Mazor Moshe Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Holcberg Gershon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Zlotnik Alexander Department of Anesthesiology, Soroka University Medical Center, Beersheba, Israel aut Sheiner Eyal Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 707-710 0932-0067 283:4<707 2011 283 404 https://doi.org/10.1007/s00404-010-1448-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1448-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Test Gidon The Joyce and Irving Goldman Medical School, Beersheba, Israel aut NATIONALLICENCE 700 1- Levy Amalia Department of Epidemiology and Health Services Evaluation, Soroka University Medical Center, Beersheba, Israel aut NATIONALLICENCE 700 1- Wiznitzer Arnon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 700 1- Mazor Moshe Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 700 1- Holcberg Gershon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 700 1- Zlotnik Alexander Department of Anesthesiology, Soroka University Medical Center, Beersheba, Israel aut NATIONALLICENCE 700 1- Sheiner Eyal Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 707-710 0932-0067 283:4<707 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer