caa a22 4500 445307870 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1474-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1474-5 Twelve cases of metaplastic carcinoma of the breast: experience of the university hospital of Fez Morocco [Elektronische Daten] [Kaoutar Znati, Sanaa Chahbouni, Nawal Hammas, Sanaa Bennis, Fouad Abbas, Taoufiq Harmouch, Laila Chbani, Hind Elfatemi, Afaf Amarti] Introduction: Metaplastic breast carcinoma (MBC) is a distinct invasive breast carcinoma. It is a rare and heterogeneous group of malignancies, generally characterized by hormone receptor and human epidermal growth factor receptor 2 (HER2) negativity. The aim of the study is to evaluate epidemiological aspects, clinical characteristics, pathological features and biological profile of MBC cases diagnosed in our institution. Methods: All patients with MBC diagnosed and treated in our institution between January 2004 and June 2009 were included. Results: Twelve patients were identified. The median age was 46.5 (range 35-57years) and the average tumor size was 6.9cm (3.5-18cm). Seven cases were purely squamous cell carcinomas, one was an adenosquamous carcinoma and four cases were mixed epithelial and mesenchymal metaplastic carcinomas. Primary treatment was mastectomy in 11 patients and wide local excision in one patient. There was lymph node (LN) involvement in four patients. Three patients were stage IIA, eight were stage III (2 IIIA, 6 IIIB), and one was stage IV. Estrogen and progesterone receptors status and over expression of HER2 were assessed. Eleven tumors had a basal-like phenotype and one tumor had luminal B phenotype. Conclusion: This study found a high incidence of MBC compared to Western countries. The tumors occur at an earlier age of onset and are usually diagnosed at a late stage with predominance of squamous cell carcinoma subtype. LN metastases are found in the third case and the tumors are most often basal-like phenotype significantly reducing therapeutic options. Springer-Verlag, 2010 Metaplastic breast carcinoma nationallicence Classification nationallicence Morphology nationallicence Basal-like phenotype nationallicence Histogenesis nationallicence Znati Kaoutar Résidence Belair, Immeuble C Appartement 4, Route Immouzzer, Fez, Morocco aut Chahbouni Sanaa Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut Hammas Nawal Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut Bennis Sanaa Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut Abbas Fouad Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut Harmouch Taoufiq Department of Pathology, HASSAN II Teaching Hospital, Fez, Morocco aut Chbani Laila Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut Elfatemi Hind Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut Amarti Afaf Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 845-849 0932-0067 283:4<845 2011 283 404 https://doi.org/10.1007/s00404-010-1474-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1474-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Znati Kaoutar Résidence Belair, Immeuble C Appartement 4, Route Immouzzer, Fez, Morocco aut NATIONALLICENCE 700 1- Chahbouni Sanaa Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut NATIONALLICENCE 700 1- Hammas Nawal Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut NATIONALLICENCE 700 1- Bennis Sanaa Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut NATIONALLICENCE 700 1- Abbas Fouad Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut NATIONALLICENCE 700 1- Harmouch Taoufiq Department of Pathology, HASSAN II Teaching Hospital, Fez, Morocco aut NATIONALLICENCE 700 1- Chbani Laila Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut NATIONALLICENCE 700 1- Elfatemi Hind Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut NATIONALLICENCE 700 1- Amarti Afaf Department of Pathology, HASSAN II University Hospital, Fez, Morocco aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 845-849 0932-0067 283:4<845 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer