caa a22 4500 445307897 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1452-y doi (NATIONALLICENCE)springer-10.1007/s00404-010-1452-y Age-independent first trimester screening for Down syndrome: analysis of three modified software programs with 6,508 pregnancies [Elektronische Daten] [C. Hörmansdörfer, M. Golatta, A. Scharf, P. Hillemanns, P. Schmidt] Background: The conventional first trimester screening (FTS) method integrates maternal age into risk calculation. It was suggested that this concept increases the false-positive rate in older, and the false-negative rate in younger mothers. Materials and methods: Six thousand five hundred and eight combined FTS with known fetal outcome underwent regular risk calculation with the software programs Pia fetal database (PIA) (GE-ViewPoint, GE Medical Systems), prenatal risk calculation (PRC) (Version 1.0.61, gmt/nexus), and JOY (Version 2.1, PET software). The results were mathematically modified as if generated with age-independent software (PIAmod, PRCmod, and JOYmod). Results: 17 of 40 trisomy 21 cases were present in women younger than 35. A right shift in the mean maternal age of false-negative cases occurred in all programs (PIA: 30.00, PIAmod: 32.00, PRC: 30.00, PRCmod: 32.25, JOY: 30.00, JOYmod: 34.50). The overall false-positive rate declined by −40.03% (PIAmod), −38.64% (PRCmod), and −37.50% (JOYmod) and in women over 35 (40)years by −72.37, −73.45, and −73.20% (−89.04, −90.33, and −90.56%), being then as high as in the other age groups. Conclusion: First trimester screening would become reasonable in women over 40years. However, women over 35 would also be more often affected by false-negative results. The implications of a concept adaptation should be analyzed in a large prospective study. Springer-Verlag, 2010 First trimester nationallicence Trisomy 21 nationallicence Down syndrome nationallicence Aneuploidy nationallicence Maternal age nationallicence Hörmansdörfer C. Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Golatta M. Department of Obstetrics and Gynaecology, Medical University of Heidelberg, Heidelberg, Germany aut Scharf A. Department of Obstetrics and Gynaecology, Medical University of Heidelberg, Heidelberg, Germany aut Hillemanns P. Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Schmidt P. Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 749-754 0932-0067 283:4<749 2011 283 404 https://doi.org/10.1007/s00404-010-1452-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1452-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hörmansdörfer C. Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Golatta M. Department of Obstetrics and Gynaecology, Medical University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Scharf A. Department of Obstetrics and Gynaecology, Medical University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Hillemanns P. Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Schmidt P. Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 749-754 0932-0067 283:4<749 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer