caa a22 4500 445307943 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1433-1 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1433-1 p57KIP2 immunohistochemical expression: a useful diagnostic tool in discrimination between complete hydatidiform mole and its mimics [Elektronische Daten] [Soheila Sarmadi, Narges Izadi-Mood, Ali Abbasi, Sanaz Sanii] Purpose: The purpose of this study was to evaluate the results of immunohistochemical expression of p57KIP2 in the complete hydatidiform mole (CHM) and other types of hydropic pregnancy. Background: Classification of molar pregnancies is typically defined by histologic and genetic criteria. The histologic criteria are subjective and demonstrate considerable interobserver variability. Several studies have recently shown that immunohistochemical detection of p57KIP2 expression in molar pregnancies is a useful ancillary diagnostic tool. The p57KIP2 gene is strongly paternally imprinted and maternally expressed. The villous cytotrophoblastic cells of complete hydatidiform mole (CHM) lack the maternal genome, that's why they reveal negative immunostaining for p57KIP2. On the contrary, in villous cytotrophoblastic cells of partial hydatidiform mole (PHM) and hydropic abortion, immunohistochemical staining for this marker is positive. Methods: We performed p57KIP2 immunohistochemical staining in 89 cases in four histological diagnostic categories as follows: "CHM” (n=22), "PHM” (n=32), "hydatidiform mole (HM)” (where the histological features were insufficient to differentiate between CHM and PHM) (n=20), and "suggestive for PHM” (n=15). Results: p57KIP2 expression in villous cytotrophoblasts and stromal cells was absent or markedly reduced in 22 of 22 "CHMs”, 7 of 32 "PHMs”, 15 of 20 "HMs”, and 1 of 15 "suggestive for PHMs” (P<0.001). In all cases, maternal decidua and syncytiotrophoblast, respectively, showed diffuse and strong p57KIP2 expression, and negative p57KIP2 expression. Conclusions: This study confirms that negative p57KIP22 immunostaining may reliably identify CHM irrespective of gestational age and can be used in association with the histological findings to distinguish CHM from its mimics in challenging cases. Springer-Verlag, 2010 p57KIP2 nationallicence Complete hydatidiform mole nationallicence Partial hydatidiform mole nationallicence Hydropic abortion nationallicence CHM : Complete hydatidiform mole nationallicence GTD : Gestational trophoblastic disease nationallicence HA : Hydropic abortion nationallicence HM : Hydatidiform mole nationallicence IHC : Immunohistochemistry nationallicence PHM : Partial hydatidiform mole nationallicence Sarmadi Soheila Department of Pathology, Mirza Koochak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Izadi-Mood Narges Department of Pathology, Mirza Koochak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Abbasi Ali Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Sanii Sanaz Department of Pathology, Mirza Koochak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 743-748 0932-0067 283:4<743 2011 283 404 https://doi.org/10.1007/s00404-010-1433-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1433-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sarmadi Soheila Department of Pathology, Mirza Koochak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Izadi-Mood Narges Department of Pathology, Mirza Koochak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Abbasi Ali Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Sanii Sanaz Department of Pathology, Mirza Koochak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 743-748 0932-0067 283:4<743 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer