caa a22 4500 445308052 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1459-4 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1459-4 A significant linear association exists between advanced maternal age and adverse perinatal outcome [Elektronische Daten] [Shimrit Salem Yaniv, Amalia Levy, Arnon Wiznitzer, Gershon Holcberg, Moshe Mazor, Eyal Sheiner] Objective: The present study was aimed to investigate perinatal outcome of elderly nulliparous patients. Study design: A retrospective study was performed comparing pregnancy outcomes of nulliparous patients at three age groups: less than 35years (reference group), 35-40years, and above 40years. The linear-by-linear association test was used to examine linear association between advanced maternal age and adverse pregnancy outcomes. A multiple logistic regression model was used to control for confounders. Results: Out of 45,033 nulliparous women with singleton gestations, 1,036 were of women over the age of 35, and 188 over 40. A significant linear association was documented between advanced maternal age and adverse outcomes, such as intra uterine growth restriction, low birth weight, congenital malformations, and perinatal mortality. Using a multiple logistic regression model, controlling for gestational age, IUGR and malformations, advanced maternal age was not found to be an independent risk factor for perinatal mortality (adjusted odds ratio=1.04, 95% confidence interval 0.7-1.4). Conclusion: A significant linear association exists between advanced maternal age and adverse maternal and perinatal outcomes. Nevertheless, in our population, advanced maternal age is not an independent risk factor for perinatal mortality. Springer-Verlag, 2010 Advanced maternal age nationallicence Perinatal mortality nationallicence Intra uterine growth restriction nationallicence Low birth weight nationallicence Salem Yaniv Shimrit Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Levy Amalia Epidemiology and Health Evaluation Department, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel aut Wiznitzer Arnon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Holcberg Gershon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Mazor Moshe Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Sheiner Eyal Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 755-759 0932-0067 283:4<755 2011 283 404 https://doi.org/10.1007/s00404-010-1459-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1459-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salem Yaniv Shimrit Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 700 1- Levy Amalia Epidemiology and Health Evaluation Department, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel aut NATIONALLICENCE 700 1- Wiznitzer Arnon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 700 1- Holcberg Gershon Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 700 1- Mazor Moshe Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 700 1- Sheiner Eyal Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beersheba, Israel aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 755-759 0932-0067 283:4<755 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer