caa a22 4500 445308079 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1491-4 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1491-4 Serum albumin and vascular endothelial growth factor in epithelial ovarian cancer: looking at adnexal tumor drainage [Elektronische Daten] [Solange Bizzo, Débora Meira, José Lima, Jânio da Silva Mororó, Fábio de Barros Moreira, José Casali-da-Rocha, Maria Ornellas] Purpose: This study aims to analyze serum albumin levels (SAL) in relation to concentrations of vascular endothelial growth factor (VEGF) from peripheral plasma, infundibular plasma, peritoneal fluids and the peritoneal burden of VEGF of patients with epithelial ovarian cancer. Methods: Exploratory analyses of SAL in 39 patients and its relation to mean concentrations of VEGF from the origins are described above. Statistical analyses comprised Student's t test, Mann-Whitney test and Pearson's and Spearman's correlation coefficient. Results: Both infundibular concentrations of VEGF and the peritoneal burden of VEGF showed significant differences between SAL dichotomized at 3g/dl. Concentrations of VEGF in peritoneal fluids were not significant in relation to SAL. Peripheral plasma VEGF levels did not show any linear correlation with SAL. Indeed, SAL showed a significant negative linear correlation (p<0.001) to infundibular plasma as well as the peritoneal burden of VEGF (p=0.004). Conclusions: Infundibular mean concentrations of VEGF may contribute to reduce SAL in advanced staging rather than the peripheral plasma concentrations of this glycoprotein. The peritoneal burden of VEGF may also aid in decreasing levels of serum albumin. Springer-Verlag, 2010 Albumin nationallicence VEGF nationallicence Ascites nationallicence Ovarian cancer nationallicence Bizzo Solange Gynecologic Oncology Service, National Cancer Institute, Rio de Janeiro, Brazil aut Meira Débora Division of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil aut Lima José Gynecologic Oncology Service, National Cancer Institute, Rio de Janeiro, Brazil aut da Silva Mororó Jânio Division of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil aut de Barros Moreira Fábio Pathology Division, National Cancer Institute, Rio de Janeiro, Brazil aut Casali-da-Rocha José National Tumor Bank, Research Center, National Cancer Institute, Rio de Janeiro, Brazil aut Ornellas Maria Department of Pathology, Rio de Janeiro State University, Rio de Janeiro, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 855-859 0932-0067 283:4<855 2011 283 404 https://doi.org/10.1007/s00404-010-1491-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1491-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bizzo Solange Gynecologic Oncology Service, National Cancer Institute, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- Meira Débora Division of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- Lima José Gynecologic Oncology Service, National Cancer Institute, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- da Silva Mororó Jânio Division of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- de Barros Moreira Fábio Pathology Division, National Cancer Institute, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- Casali-da-Rocha José National Tumor Bank, Research Center, National Cancer Institute, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- Ornellas Maria Department of Pathology, Rio de Janeiro State University, Rio de Janeiro, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 855-859 0932-0067 283:4<855 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer