caa a22 4500 445308095 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1434-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1434-0 Efficacy of anti-tumor necrosis factor therapy on endometriosis in an experimental rat model [Elektronische Daten] [Ebru Zulfikaroglu, Sevtap Kılıc, Mine Islimye, Murat Aydin, Sema Zergeroglu, Sertac Batioglu] Objective: To show the efficacy of anti-tumor necrosis factor therapy (etanercept) for treating endometriosis in an experimental model. Design: A randomized, placebo-controlled, blinded study using rat endometriosis model. Setting: Experimental research center of Ankara Education and Research Hospital. Animal(s): Twenty-two Wistar female rats. Intervention(s): After peritoneal implantation of endometrial tissue, rats were randomized to two equal intervention groups: control and etanercept-treated groups. After measuring implant volume, blood and peritoneal fluid samples were obtained. Vehicle treatments of 2mL saline to rats in control and 0.4mg/kg etanercept SC once weekly were administered in treatment group. Four weeks later, a third laparotomy was performed to remeasure implant volumes, blood, and peritoneal fluid samples. Main outcome measure(s): To compare spherical volume, peritoneal fluid and serum levels of VEGF, IL-6, and TNF-α between groups. Result(s): There was a significant difference in spherical volume between control [131.0 (60.3-501.2)] and treatment groups [72.8 (31.2-149.6)] (p<0.025). In etanercept-treated group, a significant difference was found between peritoneal fluid and serum levels of VEGF, IL-6, and TNF-α (p<0.01). Conclusion(s): These results indicate that etanercept was found to effectively reduce the development of endometriosis. Springer-Verlag, 2010 Experimental endometriosis nationallicence Etanercept nationallicence Peritoneal fluid nationallicence Serum nationallicence IL-6 nationallicence VEGF nationallicence TNF-α nationallicence VEGF : Vascular endothelial growth factor nationallicence IL-6 : Interleukin-6 nationallicence TNF-α : Tumor necrosis factor-α nationallicence Zulfikaroglu Ebru Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut Kılıc Sevtap Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut Islimye Mine Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut Aydin Murat Department of Biochemistry, Fatih University School of Medicine, Ankara, Turkey aut Zergeroglu Sema Department of Pathology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, Ankara, Turkey aut Batioglu Sertac Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 799-804 0932-0067 283:4<799 2011 283 404 https://doi.org/10.1007/s00404-010-1434-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1434-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zulfikaroglu Ebru Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut NATIONALLICENCE 700 1- Kılıc Sevtap Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut NATIONALLICENCE 700 1- Islimye Mine Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut NATIONALLICENCE 700 1- Aydin Murat Department of Biochemistry, Fatih University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Zergeroglu Sema Department of Pathology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Batioglu Sertac Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 7.Cadde 70 A/14, Bahcelievler, 06490, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 799-804 0932-0067 283:4<799 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer