caa a22 4500 445308125 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-010-1530-1 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1530-1 The role of HPV DNA testing in the follow-up of cervical intraepithelial neoplasia after loop electrosurgical excision procedure [Elektronische Daten] [Nasuh Dogan, Mehmet Salman, Kunter Yuce] Objectives: To assess human papilloma viruses (HPV) DNA test for detection of recurrences in cervical intraepithelial neoplasia (CIN) patients after loop electrosurgical excision procedure (LEEP). Also effect of LEEP on the clearance of HPV infection was evaluated for CIN 1 lesions. Methods: HPV DNA positive 37 patients (25 CIN 2-3 and 12 CIN 1 cases proven by colposcopic biopsies) were treated with LEEP and followed prospectively with HPV DNA and cytology at third and sixth months. Results: There were 11 patients with abnormal cytologic results in third month and 4 in sixth month. HPV DNA positivity rate declined in CIN 1 group between third and sixth month but this did not reach to statistical significance (44 vs. 36%, P=0.41). There were 3 treatment failures out of 37 patients (8.1%). All these three patients had CIN 3 at the beginning and two of them had positive HPV DNA in two controls. There were no recurrence/treatment failure for CIN 1 patients. Regarding 37 patients, decrease in cytologic abnormality incidence between third and sixth-month control was statistically significant (29.7 vs. 10.9%, P=0.03). All four patients with cytologic abnormality at the sixth month had HPV persistence. Cytologic abnormality was more prevelant in HPV persistent women (P=0.01) and also there was no cytologic abnormality in case of HPV DNA negativity. Conclusion: LEEP does not seem to decrease HPV DNA incidence for CIN 1 at least for 6months. But HPV DNA used in addition to cytology might help to detect recurrences. Springer-Verlag, 2010 Persistent HPV infection nationallicence LEEP nationallicence Cervical intraepithelial neoplasia nationallicence Dogan Nasuh Zekai Tahir Burak Maternity Hospital, Ankara, Turkey aut Salman Mehmet Faculty of Medicine, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey aut Yuce Kunter Faculty of Medicine, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 871-877 0932-0067 283:4<871 2011 283 404 https://doi.org/10.1007/s00404-010-1530-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1530-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dogan Nasuh Zekai Tahir Burak Maternity Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Salman Mehmet Faculty of Medicine, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey aut NATIONALLICENCE 700 1- Yuce Kunter Faculty of Medicine, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 871-877 0932-0067 283:4<871 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer