caa a22 4500 445308133 CHVBK 20180317142619.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00404-011-1848-3 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1848-3 Obstetric outcome following cervical conization [Elektronische Daten] [Sharon Armarnik, Eyal Sheiner, Benjamin Piura, Mihai Meirovitz, Alexander Zlotnik, Amalia Levy] Objective: The purpose of the present study was to examine obstetric outcome of patients following conization and specifically the risk for preterm delivery (PTD). Methods: A population-based study was performed comparing pregnancies in women following conization with those who had not undergone the procedure. Stratified analysis, using a multiple logistic regression model was performed to control for confounders. Results: Out of 104,670 deliveries, 53 women (0.05%) had undergone conization. Most conizations were performed using loop electrosurgical excision procedure (LEEP). Using multivariable analysis, the following conditions were significantly associated with conization: advanced maternal age, PTD before the 34th week, low birth weight, and cervical incompetence with cerclage. Higher rates of perinatal mortality were noted in pregnancies of women with conization, but after controlling for PTD, the association lost its significance. The risk of PTD <34weeks was significantly higher than the comparison group (OR 7.73 95% CI 3.77-15.85, p<0.001). This association remained significant after controlling for confounders, such as cervical incompetence, smoking, maternal age, birth order and year of delivery (OR 2.8 95% CI 1.3-6.1, p=0.008). When comparing pregnancy outcomes of women with and without cerclage due to cervical incompetence, no significant differences were documented. Conclusions: A clear association exists between conization and PTD before the 34th week. This association persists after controlling for variables considered to coexist with PTD. Carful surveillance is required in pregnancies of women following conization for early detection of preterm contractions and PTD. Springer-Verlag, 2011 Conization nationallicence Cold knife nationallicence Loop electrosurgical excision procedure (LEEP) nationallicence Cerclage nationallicence Premature rupture of membranes (PROM) nationallicence Armarnik Sharon Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut Sheiner Eyal Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut Piura Benjamin Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut Meirovitz Mihai Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut Zlotnik Alexander Department of Anesthesiology, Soroka University Medical Center, 151, 84101, Beer-Sheva, Israel aut Levy Amalia Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel aut Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 765-769 0932-0067 283:4<765 2011 283 404 https://doi.org/10.1007/s00404-011-1848-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1848-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Armarnik Sharon Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut NATIONALLICENCE 700 1- Sheiner Eyal Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut NATIONALLICENCE 700 1- Piura Benjamin Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut NATIONALLICENCE 700 1- Meirovitz Mihai Department of Obstetrics and Gynecology, Soroka University Medical Center, 151, 84105, Beer-Sheva, Israel aut NATIONALLICENCE 700 1- Zlotnik Alexander Department of Anesthesiology, Soroka University Medical Center, 151, 84101, Beer-Sheva, Israel aut NATIONALLICENCE 700 1- Levy Amalia Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/4(2011-04-01), 765-769 0932-0067 283:4<765 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer