caa a22 4500 445308184 CHVBK 20180317142620.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1552-8 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1552-8 Terada Tadashi Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu-Ku, 424-8636, Shizuoka, Japan aut Sarcomatoid squamous cell carcinoma of the vulva expressing smooth muscle actin and S100 protein [Elektronische Daten] [Tadashi Terada] Introduction: Vulvar sarcomatoid squamous cell carcinoma has been rarely reported. Methods: Case report and immunohistochemistry. Results: The author herein reports a peculiar vulvar tumor. An 87-year-old woman with hypertension presented with a vulvar tumor, and admitted to our hospital. Gross examination showed an elevated tumor measuring 3×4×5cm in the vulva near the urethra. An excisional biopsy was taken, and it showed proliferation and invasion of malignant spindle cells (70% in area) and malignant polygonal cells (30% in area). There were gradual transitions between vulvar squamous epithelium and these malignant tumor cells. Immunohistochemically, the malignant sarcomatoid cells (spindle and polygonal cells) were positive for cytokeratins, epithelial membrane antigen, vimentin, α-smooth muscle actin, S100 protein, and p53 protein. They were negative for melanosome, CD34, CD68, myoglobin, and CD45. Ki-67 labeling was 63%. A pathological diagnosis of sarcomatoid squamous cell carcinoma expressing smooth muscle antigen and S100 protein was made. The patient developed lung metastasis 2months later, and suddenly died of unknown cause. Conclusion: A rare case of vulvar sarcomatoid squamous cell carcinoma expressing S100 protein and α-smooth muscle actin is reported. Springer-Verlag, 2010 Vulva nationallicence Sarcomatoid squamous cell carcinoma nationallicence Immunohistochemistry nationallicence Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1103-1106 0932-0067 283:5<1103 2011 283 404 https://doi.org/10.1007/s00404-010-1552-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1552-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Terada Tadashi Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu-Ku, 424-8636, Shizuoka, Japan aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1103-1106 0932-0067 283:5<1103 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer