caa a22 4500 445308230 CHVBK 20180317142620.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1487-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1487-0 Effects of estradiol-drospirenone hormone treatment on carotid artery intima-media thickness and vertigo/dizziness in postmenopausal women [Elektronische Daten] [Hakan Coksuer, Mustafa Koplay, Fatih Oghan, Cengiz Coksuer, Nadi Keskin, Olcay Ozveren] Aim: To investigate the effects of Angeliq on hormonal, metabolic, biochemical and cardiovascular profile, carotid intima-media thickness (CIMT) and vertigo/dizziness symptoms in postmenopausal women. Methods: Angeliq is a drug used for hormone replacement therapy that composed of drospirenone 2mg and estradiol 1mg. Thirty-two postmenopausal women were recruited for the study. All women were evaluated using personal interview, medical examination and carotid artery ultrasound. They were questioned specifically about vertigo/dizziness experienced. Participants were randomly submitted to oral daily treatment with Angeliq. The duration of the study was 6months and the participants were studied in basal condition and after 6months of the therapy. Results: Follicle-stimulating hormone was significantly higher and estradiol was significantly lower in before therapy (BT) than in after therapy (AT) (p<0.001). No differences in fasting glucose, CRP and WBC values, and lipid-lipoprotein profile were detected between the groups. The systolic and diastolic blood pressures and heart rate were also significantly higher in BT than in AT (p<0.05). A significant (p<0.001) difference in CIMT (0.51±0.04 vs. 0.49±0.03mm) was found between BT and AT. Seven of 32 patients (22%) had vertigo/dizziness symptoms before treatment. After 6months, none of the patients showed complaints of vertigo/dizziness. Conclusions: Oral daily treatment with Angeliq reduces CIMT and climacteric complaints including vertigo/dizziness in postmenopausal women. They may relate to anti-androgenic and anti-mineralocorticoid effects of Angeliq, respectively. Springer-Verlag, 2010 Cardiovascular disease nationallicence Carotid intima-media thickness nationallicence Drospirenone nationallicence Menopause nationallicence Vertigo/dizziness nationallicence AT : After therapy nationallicence BT : Before therapy nationallicence BMI : Body mass index nationallicence CHD : Coronary heart disease nationallicence CIMT : Carotid intima-media thickness nationallicence CRP : C-reactive protein nationallicence DBP : Diastolic blood pressure nationallicence DRSP/E2 : Drospirenone-estradiol nationallicence E2 : Estradiol nationallicence FSH : Follicle-stimulating hormone nationallicence HRT : Hormone replacement therapy nationallicence HDL : High-density lipoprotein nationallicence PW : Postmenopausal women nationallicence SBP : Systolic blood pressure nationallicence TC : Total cholesterol nationallicence TG : Triglycerides nationallicence LDL : Low-density lipoprotein nationallicence WBC : White blood cells count nationallicence Coksuer Hakan Department of Obstetrics and Gynecology, Faculty of Medicine, School of Medicine, Dumlupınar University, Central Campus, 43270, Kutahya, Turkey aut Koplay Mustafa Department of Radiology, School of Medicine, Dumlupinar University, Kutahya, Turkey aut Oghan Fatih Department of Otorhinolaryngology, School of Medicine, Dumlupinar University, Kutahya, Turkey aut Coksuer Cengiz Cizre State Hospital, Kutahya, Turkey aut Keskin Nadi Department of Obstetrics and Gynecology, Faculty of Medicine, School of Medicine, Dumlupınar University, Central Campus, 43270, Kutahya, Turkey aut Ozveren Olcay Department of Cardiology, School of Medicine, Dumlupinar University, Kutahya, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1045-1051 0932-0067 283:5<1045 2011 283 404 https://doi.org/10.1007/s00404-010-1487-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1487-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Coksuer Hakan Department of Obstetrics and Gynecology, Faculty of Medicine, School of Medicine, Dumlupınar University, Central Campus, 43270, Kutahya, Turkey aut NATIONALLICENCE 700 1- Koplay Mustafa Department of Radiology, School of Medicine, Dumlupinar University, Kutahya, Turkey aut NATIONALLICENCE 700 1- Oghan Fatih Department of Otorhinolaryngology, School of Medicine, Dumlupinar University, Kutahya, Turkey aut NATIONALLICENCE 700 1- Coksuer Cengiz Cizre State Hospital, Kutahya, Turkey aut NATIONALLICENCE 700 1- Keskin Nadi Department of Obstetrics and Gynecology, Faculty of Medicine, School of Medicine, Dumlupınar University, Central Campus, 43270, Kutahya, Turkey aut NATIONALLICENCE 700 1- Ozveren Olcay Department of Cardiology, School of Medicine, Dumlupinar University, Kutahya, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1045-1051 0932-0067 283:5<1045 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer