caa a22 4500 445308281 CHVBK 20180317142620.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1482-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1482-5 Comparison of prolidase enzyme activities of maternal serum and placental tissue in patients with early pregnancy failure [Elektronische Daten] [Mehmet Vural, Harun Toy, Hakan Camuzcuoglu, Nurten Aksoy] Purpose: To compare the maternal serum and placental tissue levels of prolidase enzyme activity in women with early pregnancy loss (EPL) with those of women who underwent elective dilatation and curettage (D&C). Methods: Serum and placental tissue samples from 52 women with early pregnancy loss (study group) and 49 women who underwent elective D&C (control group) were collected. Criteria for inclusion in the study group were based on evidence of vaginal bleeding, transvaginal ultrasonography results, and clinical findings. Prolidase enzyme activity was determined using a photometric method. Results: Serum levels of prolidase activity were lower in the early pregnancy loss group than in the control group (p<0.001). However, placental tissue activity levels were significantly higher among women with an EPL than among women without an EPL (p<0.001). Conclusion: Results from this study demonstrate an inverse relationship of serum and placental levels of prolidase activity. Placental utilization of the prolidase enzyme may explain the low serum levels. As prolidase is a marker of collagen turnover, we conclude that collagen turnover is increased in patients with early pregnancy loss and may be an etiopathological factor of this disease. Springer-Verlag, 2010 Prolidase nationallicence Early pregnancy loss nationallicence Placenta nationallicence Vural Mehmet Department of Obstetrics and Gynecology, School of Medicine, Harran University, Morfoloji Binasi, Kat 3, Yenisehir, 63300, Sanliurfa, Turkey aut Toy Harun Department of Obstetrics and Gynecology, School of Medicine, Harran University, Morfoloji Binasi, Kat 3, Yenisehir, 63300, Sanliurfa, Turkey aut Camuzcuoglu Hakan Department of Obstetrics and Gynecology, School of Medicine, Harran University, Morfoloji Binasi, Kat 3, Yenisehir, 63300, Sanliurfa, Turkey aut Aksoy Nurten Department of Biochemistry, School of Medicine, Harran University, Sanliurfa, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 953-958 0932-0067 283:5<953 2011 283 404 https://doi.org/10.1007/s00404-010-1482-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1482-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vural Mehmet Department of Obstetrics and Gynecology, School of Medicine, Harran University, Morfoloji Binasi, Kat 3, Yenisehir, 63300, Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Toy Harun Department of Obstetrics and Gynecology, School of Medicine, Harran University, Morfoloji Binasi, Kat 3, Yenisehir, 63300, Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Camuzcuoglu Hakan Department of Obstetrics and Gynecology, School of Medicine, Harran University, Morfoloji Binasi, Kat 3, Yenisehir, 63300, Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Aksoy Nurten Department of Biochemistry, School of Medicine, Harran University, Sanliurfa, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 953-958 0932-0067 283:5<953 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer