caa a22 4500 445308346 CHVBK 20180317142620.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1828-z doi (NATIONALLICENCE)springer-10.1007/s00404-010-1828-z Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders [Elektronische Daten] [Mohammad Karimzadeh, Mehri Mashayekhy, Farnaz Mohammadian, Fatemeh Moghaddam] Purpose: To compare the IVF outcome of clomiphene citrate/gonadotropin/antagonist (mild protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in vitro fertilization. Methods: 159 poor responder patients were randomized and ovarian stimulation was performed with clomiphene citrate, gonadotropin and antagonist (group I) or microdose GnRH agonist flare (group II) protocols. Main outcome was clinical pregnancy rate and secondary outcomes were doses of gonadotropin administration and duration of stimulation. Results: There were no significant differences in age, causes of infertility, basal FSH, BMI, duration of infertility, E2 level on the day of hCG injection in both groups. Although the cancellation, fertilization, and clinical pregnancy rates were similar in both groups, the endometrial thickness, number of retrieved oocytes, mature oocytes and implantation rate were significantly higher in mild protocol. The doses of gonadotropin administration and duration of stimulation were significantly lower in mild protocol. Conclusion: We recommend mild protocol in assisted reproductive technology cycles for poor responders based on our results regarding less doses of used gonadotropin and a shorter duration of stimulation. Springer-Verlag, 2011 Poor responders nationallicence GnRH agonist nationallicence GnRH antagonist nationallicence Clomiphene citrate nationallicence IVF outcome nationallicence Karimzadeh Mohammad Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Bouali Avenue, Safaieh, 8916877391, Yazd, Iran aut Mashayekhy Mehri Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Sardasht Avenue, 3848176941, Arak, Iran aut Mohammadian Farnaz Department of Obstetrics and Gynecology, Zanjan University of Medical Sciences, Azadi Avenue, 1319145156, Zanjan, Iran aut Moghaddam Fatemeh Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Bouali Avenue, Safaieh, 8916877391, Yazd, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1159-1164 0932-0067 283:5<1159 2011 283 404 https://doi.org/10.1007/s00404-010-1828-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1828-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karimzadeh Mohammad Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Bouali Avenue, Safaieh, 8916877391, Yazd, Iran aut NATIONALLICENCE 700 1- Mashayekhy Mehri Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Sardasht Avenue, 3848176941, Arak, Iran aut NATIONALLICENCE 700 1- Mohammadian Farnaz Department of Obstetrics and Gynecology, Zanjan University of Medical Sciences, Azadi Avenue, 1319145156, Zanjan, Iran aut NATIONALLICENCE 700 1- Moghaddam Fatemeh Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Bouali Avenue, Safaieh, 8916877391, Yazd, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1159-1164 0932-0067 283:5<1159 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer