caa a22 4500 445308354 CHVBK 20180317142620.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1518-x doi (NATIONALLICENCE)springer-10.1007/s00404-010-1518-x Genitourinary prolapse and joint hypermobility are associated with altered type I and III collagen metabolism [Elektronische Daten] [E. Knuuti, S. Kauppila, V. Kotila, J. Risteli, Ritva Nissi] Purpose: The aim of this study was to determine whether benign joint hypermobility (BJH) is associated with urogenital prolapse and altered collagen metabolism. Methods: 43 postmenopausal women with previous vaginal hysterectomy operated due to genitourinary prolapse were recruited. Each patient was also evaluated for joint hypermobility. The collagen metabolism was studied measuring serum concentrations of type I and III procollagen aminoterminal propeptides and trivalently cross-linked carboxyterminal telopeptide of type I collagen. Results: Clinical joint hypermobility was found in 35% patients. Women with joint hypermobility had higher concentration of aminoterminal propeptide for type I procollagen and the values were statistically significant (P<0.0178). Recurrent prolapse was found in 47% of the patients with BJH as compared to non-hypermobile group (25%). In this subgroup the results were statistically significant (P<0.0085) for type III collagen. Also, the mean serum concentration for type III procollagen was significantly increased above the reference limit. Conclusions: Women with joint hypermobility have more recurrent genital prolapse as compared to women with normal joint mobility. Plain hypermobility was associated with higher concentrations for type I procollagen. Patients with recurrent prolapse and joint hypermobility have significantly high concentrations for type III procollagen. Springer-Verlag, 2010 PIIINP nationallicence PINP nationallicence ICTP nationallicence Benign joint hypermobility nationallicence Genitourinary prolapse nationallicence Knuuti E. Department of Obstetrics and Gynecology, Länsi-Pohja Central Hospital, Kemi, Finland aut Kauppila S. Department of Pathology, University Hospital of Oulu, Oulu, Finland aut Kotila V. Division of Mathematics, Department of Electrical and Information Engineering, University of Oulu, Oulu, Finland aut Risteli J. Department of Clinical Chemistry, University Hospital of Oulu, Oulu, Finland aut Nissi Ritva Department of Obstetrics and Gynecology, Länsi-Pohja Central Hospital, Kemi, Finland aut Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1081-1085 0932-0067 283:5<1081 2011 283 404 https://doi.org/10.1007/s00404-010-1518-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1518-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Knuuti E. Department of Obstetrics and Gynecology, Länsi-Pohja Central Hospital, Kemi, Finland aut NATIONALLICENCE 700 1- Kauppila S. Department of Pathology, University Hospital of Oulu, Oulu, Finland aut NATIONALLICENCE 700 1- Kotila V. Division of Mathematics, Department of Electrical and Information Engineering, University of Oulu, Oulu, Finland aut NATIONALLICENCE 700 1- Risteli J. Department of Clinical Chemistry, University Hospital of Oulu, Oulu, Finland aut NATIONALLICENCE 700 1- Nissi Ritva Department of Obstetrics and Gynecology, Länsi-Pohja Central Hospital, Kemi, Finland aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1081-1085 0932-0067 283:5<1081 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer