caa a22 4500 445308362 CHVBK 20180317142620.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1466-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1466-5 Rectal versus oral misoprostol for active management of third stage of labor: a randomized controlled trial [Elektronische Daten] [H. Mansouri, N. Alsahly] Aim of the study: To test that rectal misoprostol is effective for active management of third stage of labor, and probably with less side effects than oral misoprostol. Materials and methods: As much as 658 patients were randomly allocated to receive either 600μg misoprostol orally or rectally 5min after cord clamping and cutting. The primary outcome was incidence of postpartum hemorrhage. Secondary outcomes included amount of blood loss, duration of third stage of labor, incidence of side effects, pre- and post-delivery hemoglobin, and the use of additional uterotonics. Results: A total of 331 patients received 600μg of misoprostol orally, while 327 rectally. Both groups were comparable in demographic data and neonatal outcome. Oral misoprostol was associated with significantly more blood loss than rectal (P=0.016). Shivering and pyrexia occurred in 161 (52.1%) and 86 (27.8%) women receiving oral misoprostol, and in 81 (26.2%) and 47 (15.2%) of those who received rectal misoprostol, respectively (P=0.000 and 0.001). Conclusion: Rectal misoprostol is effective in the management of third stage of labor, and with a significant decrease in side effects. Lesser dose and other routes could be explored in the future. Springer-Verlag, 2010 Misoprostol nationallicence Active management nationallicence Third stage nationallicence Postpartum hemorrhage nationallicence Shivering nationallicence Pyrexia nationallicence Mansouri H. King Abdulaziz University Hospital, Jeddah, Saudi Arabia aut Alsahly N. King Abdulaziz University Hospital, Jeddah, Saudi Arabia aut Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 935-939 0932-0067 283:5<935 2011 283 404 https://doi.org/10.1007/s00404-010-1466-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1466-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mansouri H. King Abdulaziz University Hospital, Jeddah, Saudi Arabia aut NATIONALLICENCE 700 1- Alsahly N. King Abdulaziz University Hospital, Jeddah, Saudi Arabia aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 935-939 0932-0067 283:5<935 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer