caa a22 4500 445308397 CHVBK 20180317142620.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1479-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1479-0 Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran [Elektronische Daten] [Leila Aghajanpour, Farhad Mashayekhi, Farzad Rajaei] Purpose: Endometriosis is a chronic pleomorphic disorder with pelvic or systemic manifestations, and is characterized by the presence of endometrial glands and stroma. It is generally considered to involve genetic, environmental, immunological, angiogenic and endocrine processes. The aim of this study was to evaluate the frequency of intercellular adhesion molecule-1 (ICAM-1) polymorphism at position 241 in exon 4 of the ICAM-1 gene in patients with endometriosis and in healthy control subjects in northern Iran. Methods: A total of 84 unrelated patients and 120 consecutive unrelated healthy controls from the northern Iran were recruited for the study. ICAM-1 codon 241 polymorphism analysis was performed by two independent PCR reactions, based on the two set of oligoprimers specific for Arg (AGG) or Gly (GGG) coding sequence, respectively. Results: Genotype distributions of ICAM-1 gene show significant difference between patients and controls. The R241 allele was detected in 23% of endometriosis patients and in 6% of controls (P=0.001; odds ratio 4.67; 95% confidence interval 1.81-12.07). Comparing patients with different stage of endometriosis, we found a trend to higher frequency of R241 in patients with stage IV (65 vs 6%; P<0.0001). Conclusion: Our results suggest that ICAM-1 polymorphism in codon 241 is associated with the development of endometriosis susceptibility in the population of northern Iran. Springer-Verlag, 2010 ICAM-1 nationallicence Endometriosis nationallicence Polymorphism nationallicence Aghajanpour Leila Department of Biology, Faculty of Sciences, University of Guilan, 1914, Rasht, Iran aut Mashayekhi Farhad Department of Biology, Faculty of Sciences, University of Guilan, 1914, Rasht, Iran aut Rajaei Farzad Department of Anatomical Sciences and Infertility Research Centre, Faculty of Medicine, Qazvin University of Medical Sciences, 34197-59811, Qazvin, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1035-1039 0932-0067 283:5<1035 2011 283 404 https://doi.org/10.1007/s00404-010-1479-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1479-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aghajanpour Leila Department of Biology, Faculty of Sciences, University of Guilan, 1914, Rasht, Iran aut NATIONALLICENCE 700 1- Mashayekhi Farhad Department of Biology, Faculty of Sciences, University of Guilan, 1914, Rasht, Iran aut NATIONALLICENCE 700 1- Rajaei Farzad Department of Anatomical Sciences and Infertility Research Centre, Faculty of Medicine, Qazvin University of Medical Sciences, 34197-59811, Qazvin, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1035-1039 0932-0067 283:5<1035 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer