caa a22 4500 445308478 CHVBK 20180317142621.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00404-010-1574-2 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1574-2 Characteristics and prognosis of coexisting adnexa malignancy with endometrial cancer: a single institution review of 51 cases [Elektronische Daten] [Lu Chen, Qiang Zhao, Xiaojuan Lv] Objective: To explore and compare the differences in the clinicopathological characteristics and prognosis of synchronous primary endometrial and ovarian cancers with primary endometrial cancer metastatic to adnexa. Materials and methods: Between January 1997 and December 2009, 51 cases with endometrial cancer simultaneously with adnexa malignancy were identified. Among them, there were 18 cases with synchronous primary cancers of the endometrium and ovary (Group A) and 33 cases with primary endometrial cancer metastatic to the adnexa (Group B). Clinical and pathologic information was obtained from medical records. Parametric methods were used to compare clinical and pathologic features. Kaplan-Meier survival analysis was performed and compared using log-rank test. Results: The mean age at diagnosis of the disease was 56.6±10.8years (range 34-76years) in Group A and 53.1±9.5years (range 37-76years) in Group B. The two groups' distribution of preoperative image findings, size of endometrial lesion, myometrial invasion, unilateral or bilateral, cervix invasion, and postoperative radiation existed significant differences. With a mean follow-up time of 4.3±3.4years (range 2-11years), 5-year overall survival (OS) was 75 and 56% in Groups A and B, respectively (p=0.034). The univariate analysis showed only postoperative radiation and synchronous tumors were independent factors which affected OS (p=0.015; p=0.034) and progression-free survival (PFS) (p=0.015; p=0.036), respectively. Not any feature was revealed by multivariate analysis as independent prognostic factors. Conclusion: Our results showed that OS and PFS of synchronous primary ovarian cancer in patients with endometrial cancer is better than those with ovarian metastasis patients. Pre- and intra-operative, intensive and careful assessment, and strict and continuous postoperative surveillance should pay attention to the endometrial cancer patients who preserved ovary for having possibility of coexisting occult ovarian lesions. The Author(s), 2010 Endometrial neoplasm nationallicence Adnexa neoplasm nationallicence Synchronous primary cancer nationallicence Prognosis nationallicence Chen Lu Department of Gynecology Oncology, Zhejiang Provincial Cancer Hospital, 38 Guangji Road, Hangzhou, People's Republic of China aut Zhao Qiang Department of Gynecology Oncology, Zhejiang Provincial Cancer Hospital, 38 Guangji Road, Hangzhou, People's Republic of China aut Lv Xiaojuan Department of Gynecology Oncology, Zhejiang Provincial Cancer Hospital, 38 Guangji Road, Hangzhou, People's Republic of China aut Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1133-1137 0932-0067 283:5<1133 2011 283 404 https://doi.org/10.1007/s00404-010-1574-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1574-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Lu Department of Gynecology Oncology, Zhejiang Provincial Cancer Hospital, 38 Guangji Road, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Qiang Department of Gynecology Oncology, Zhejiang Provincial Cancer Hospital, 38 Guangji Road, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Lv Xiaojuan Department of Gynecology Oncology, Zhejiang Provincial Cancer Hospital, 38 Guangji Road, Hangzhou, People's Republic of China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/5(2011-05-01), 1133-1137 0932-0067 283:5<1133 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer