caa a22 4500 445308583 CHVBK 20180317142621.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-010-1456-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1456-7 Schindler Adolf Institute for Medical Research and Education, Hufelandstrasse 55, 45122, Essen, Germany aut Dydrogesterone and other progestins in benign breast disease: an overview [Elektronische Daten] [Adolf Schindler] Progestogens appear to have a dual effect on the cell cycle in breast cells and breast cancer cells. There is initially stimulation of mitotic activity. However, continuous application leads to cell apoptosis. This depends on type, dose and length of progestogen application in relation to estrogen action. In benign breast disease the use of progestogens results not only in reduction of mastodynia, but also a reduction in breast gland size and disappearance of nodularity proven by clinical examination and follow-up including breast ultrasound. Springer-Verlag, 2010 Dydrogesterone nationallicence Progestin nationallicence Benign breast disease nationallicence Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 369-371 0932-0067 283:2<369 2011 283 404 https://doi.org/10.1007/s00404-010-1456-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1456-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Schindler Adolf Institute for Medical Research and Education, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 369-371 0932-0067 283:2<369 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer