caa a22 4500 445308605 CHVBK 20180317142621.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-010-1588-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1588-9 Effect of cesarean section on the risk of perinatal transmission of hepatitis C virus from HCV-RNA+/HIV− mothers: a meta-analysis [Elektronische Daten] [Mohammad Ghamar Chehreh, Seyed Tabatabaei, Shahab Khazanehdari, Seyed Alavian] Background: Hepatitis C virus (HCV) vertical transmission is considered the main route of HCV infection in children. Some authors have stated that cesarean section (C/S) can reduce perinatal HCV transmission. However, the study findings are heterogeneous and high-quality studies are lacking. Aims: To evaluate the effect of mode of delivery on the risk of perinatal mother-to-infant transmission of HCV. Methods: Only the peer-reviewed published studies that compared perinatal transmission rate of HCV in elective or emergency cesarean section with vaginal delivery in HCV-RNA+/HIV− mothers were included. We applied the random effect model of DerSimonian and Laird method with heterogeneity and sensitivity analyses. Results: We identified 8 studies that involved 641 unique mother-infant pairs which fulfilled our inclusion criteria. Aggregation of study results did not show a significant decrease in HCV vertical transmission among study (mothers who underwent C/S) versus control (mothers who gave birth vaginally) patients [pooled odds ratio, 1.1 (95% CI 0.45-2.67)]. The P value was 0.35 for our test of heterogeneity. Conclusions: Our meta-analysis suggests that C/S does not decrease perinatal HCV transmission from HCV-RNA+/HIV− mothers to infants. Springer-Verlag, 2010 Meta-analysis nationallicence HCV nationallicence Cesarean section nationallicence Vaginal delivery nationallicence Vertical transmission nationallicence Ghamar Chehreh Mohammad Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut Tabatabaei Seyed Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut Khazanehdari Shahab Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut Alavian Seyed Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 255-260 0932-0067 283:2<255 2011 283 404 https://doi.org/10.1007/s00404-010-1588-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1588-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ghamar Chehreh Mohammad Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut NATIONALLICENCE 700 1- Tabatabaei Seyed Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut NATIONALLICENCE 700 1- Khazanehdari Shahab Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut NATIONALLICENCE 700 1- Alavian Seyed Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 255-260 0932-0067 283:2<255 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer