caa a22 4500 445308613 CHVBK 20180317142621.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-009-1345-0 doi (NATIONALLICENCE)springer-10.1007/s00404-009-1345-0 Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail [Elektronische Daten] [Zhen Liu, Ling Qiu, Yu-ming Chen, Yi-xiang Su] Objective: Calcium demand is increased during pregnancy. However, few randomized controlled trials examined the effects of calcium supplementation on bone mass during pregnancy. This study determined effects of calcium and milk supplementation on maternal bone mineral density (BMD) and bone turnover in pregnant Chinese women with habitual low calcium intake. Methods: In this randomized controlled trial, 36 Chinese pregnant women (24-31years, 18 gestational weeks) were randomly assigned to the following three arms (12 each): I, usual diet; II, "I”+45g milk powder (containing 350mg calcium); or III, "II”+600mg calcium/day from gestational age of 20weeks to 6weeks post-partum (PP). BMD was measured post-treatment using dual-energy X-ray absorptiometry. Dietary intakes, 24-h urinary calcium, bone resorption (urinary hydroxyproline) and formation (serum osteocalcin) biomarkers were examined at the gestational age of 20 and 34weeks, and 6weeks PP. Results: A dose-dependent relationship was observed between calcium intake and BMDs. The BMD values were significantly higher in subjects with calcium and milk supplementation than those in the controls at the whole body and spine (p<0.05) but not at the hip sites. We found significant decreases in changes of urinary hydroxyproline, and significant increases in serum osteocalcin during the intervention period in the calcium/milk intervention groups than those in the control group (all p<0.05). Conclusion: Calcium/milk supplementation during pregnancy is associated with greater BMD at the spine and whole body and suppresses bone resorption in Chinese women with habitual low calcium intake. Springer-Verlag, 2009 Calcium nationallicence Milk nationallicence Bone mineral density nationallicence Bone turnover nationallicence Pregnant women nationallicence Randomized controlled trail nationallicence Liu Zhen Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China aut Qiu Ling Department of Rehabilitation, Nanfang Hospital, Guangzhou, China aut Chen Yu-ming Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China aut Su Yi-xiang Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 205-211 0932-0067 283:2<205 2011 283 404 https://doi.org/10.1007/s00404-009-1345-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-009-1345-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Zhen Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China aut NATIONALLICENCE 700 1- Qiu Ling Department of Rehabilitation, Nanfang Hospital, Guangzhou, China aut NATIONALLICENCE 700 1- Chen Yu-ming Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China aut NATIONALLICENCE 700 1- Su Yi-xiang Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 205-211 0932-0067 283:2<205 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer