caa a22 4500 445308680 CHVBK 20180317142621.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-009-1344-1 doi (NATIONALLICENCE)springer-10.1007/s00404-009-1344-1 Vascular endothelial growth factor +405 C/G polymorphism is highly associated with an increased risk of endometriosis in Turkish women [Elektronische Daten] [S. Altinkaya, Mustafa Ugur, Gulay Ceylaner, Mustafa Ozat, Tayfun Gungor, Serdar Ceylaner] Objective: Endometriosis is a chronic gynecological disease characterized by the growth of hormonally responsive, endometrial tissue outside the uterine cavity. The present study aims to analyze two vascular endothelial growth factor (VEGF) polymorphisms (−460 C/T and +405 C/G) in Turkish women with and without endometriosis. Study design: A case-control study was undertaken at the Infertility Department of Zekai Tahir Burak Women's Health Care Education and Research Hospital. The single nucleotide polymorphisms, −460 C/T and +405 C/G, in the 5′-untranslated region of the VEGF gene were tested in 98 affected women and 94 women with no laparoscopic evidence of disease. Endometriosis was also confirmed histologically. Following genomic extraction of genomic DNA, genotyping of the −460 C/T and +405 C/G polymorphisms of the VEGF gene were performed by polymerase chain reaction and restriction fragment length polymorphism assay. Nominal data were evaluated by Pearson Chi-square or Fisher's Exact test, where applicable. Odds ratios and 95% confidence intervals were also calculated. A P value less than 0.05 was considered statistically significant. Results: Demographic data were similar among groups. The genotype and allele frequencies of the −460 C/T polymorphism did not differ significantly between cases and controls. In contrast, the genotype (P<0.001) and allele frequencies (P<0.001) of +405 C/G polymorphism showed a significant difference between cases and controls. Regardless of the early or advanced stage, women with endometriosis showed a higher incidence of the +405 GC genotype and +405G allele when compared with the controls. Conclusions: These data suggest that VEGF +405 GC genotype and +405G allele may be associated with the risk of developing early and advanced stage endometriosis in the Turkish population. Springer-Verlag, 2009 Endometriosis nationallicence VEGF gene polymorphism nationallicence Infertility nationallicence Altinkaya S. Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut Ugur Mustafa Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut Ceylaner Gulay Intergen Genetics Center, Ankara, Turkey aut Ozat Mustafa Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut Gungor Tayfun Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut Ceylaner Serdar Intergen Genetics Center, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 267-272 0932-0067 283:2<267 2011 283 404 https://doi.org/10.1007/s00404-009-1344-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-009-1344-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altinkaya S. Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ugur Mustafa Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ceylaner Gulay Intergen Genetics Center, Ankara, Turkey aut NATIONALLICENCE 700 1- Ozat Mustafa Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Gungor Tayfun Department of Infertility, Zekai Tahir Burak Women's Health Care Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ceylaner Serdar Intergen Genetics Center, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 267-272 0932-0067 283:2<267 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer