caa a22 4500 445308699 CHVBK 20180317142621.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-010-1421-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1421-5 Predictors of atypical squamous cell of undetermined significance cervical cytology with high-risk human papilloma virus genotypes [Elektronische Daten] [Jonah Musa, Babafemi Taiwo, Susan Goldsmith, Sarah Sutton, Baiba Berzins, Robert Murphy] Objective: To investigate epidemiological factors that predicts high-risk human papillomavirus (HR-HPV) types among women with atypical squamous cells of undetermined significance (ASCUS). Methods: Case-control study of women with ASCUS and ‘reflex' HR-HPV DNA test results at the Prentice Ambulatory Care (PAC) outpatient clinic, Northwestern University, Chicago, USA. Univariate analysis and logistic regression were done to generate measures of association between various epidemiological variables and positive HR-HPV. Results: A total of 2,539 women had liquid-based Pap smear and 126 (4.96%) were confirmed ASCUS. Of the 126 with ASCUS, 125 (99.2%) had ‘reflex' HR-HPV results. The prevalence of HR-HPV among women with ASCUS was 43.2%. Among the 54 with a positive HR-HPV, 76.0% were women <30years and 24.0% were ≥30years. The prevalence of HR-HPV was 61.2% among women <30years versus 22.4% among women ≥30years (P<0.001). The mean age and standard deviations (SD) was 26.5 (6.2years) and 34.6 (10.2years) for women with a positive HR-HPV and negative HR-HPV test, respectively (P<0.001). Age category <30years was independently predictive of HR-HPV (adjusted odds ratio 4.6, 95% CI 2.0-10.7; P<0.001). Conclusion: Age <30years significantly predicts presence of HR-HPV types among women with diagnosis of ASCUS. A strategy of limiting HPV testing to older women and referral of those <30years for colposcopic assessment appears more effective. Springer-Verlag, 2010 Predictors nationallicence HR-HPV types nationallicence ASCUS nationallicence Cervical cytology nationallicence Musa Jonah Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut Taiwo Babafemi Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut Goldsmith Susan Prentice Women Hospital, Northwestern University, 60611, Chicago, IL, USA aut Sutton Sarah Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut Berzins Baiba Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut Murphy Robert Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 343-348 0932-0067 283:2<343 2011 283 404 https://doi.org/10.1007/s00404-010-1421-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1421-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Musa Jonah Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Taiwo Babafemi Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Goldsmith Susan Prentice Women Hospital, Northwestern University, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Sutton Sarah Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Berzins Baiba Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Murphy Robert Division of Infectiuous Diseases, Northwestern University, 60611, Chicago, IL, USA aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 343-348 0932-0067 283:2<343 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer