caa a22 4500 445308893 CHVBK 20180317142622.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-010-1440-2 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1440-2 Cephalothoracopagus, janiceps, disymmetros, monoomphalian conjoined twins undiagnosed until early second trimester [Elektronische Daten] [Gabriele Tonni, Alessandro Ventura, Ida Vito, Daniela Piana, Maria Bonasoni, Claudio De Felice] Introduction: Cephalothoracopagus is the less common type of conjoined twins (CTs) with an incidence estimated at one in three million births or one in 58 conjoined twins. Maternal gene Vg1, a member of the TGF-beta family of cell-signalling molecules which are implicated in dorsoanterior development, and specific actions of Hox and Pax genes that are implicated in very early embryogenesis may be identified as aetiologic factors. Materials and methods: A prenatal diagnosis of cephalothoracopagus CTs diagnosed at 17 weeks in a woman undergoing amniocentesis for advanced maternal age is reported. Conclusion: Although first-trimester diagnosis of CTs is feasible and has been reported as early as 8 weeks's gestation, CTs may be misdiagnosed with monoamniotic twins, lymphangioma, teratoma, and/or neoplasm and may be undiagnosed until early second trimester. Three-dimensional and color Doppler ultrasound enabled precise prenatal visualization of the fusion site. Ultrafast MR imaging should be considered an adjunct to ultrasound for antenatal characterization of structural anomalies and for planning surgical separation in selected cases. Echocardiography is mandatory in all cases of CTs as congenital heart defects are seen in 20-30% and polyhydramnios in 50-75%. Neural tube and midline fusion defects, diaphragmatic hernia, and imperforate anus are the frequently associated abnormalities. Prognosis among survivors is usually poor (44% die in the neonatal period) and is dependent upon the type of conjunction, degree of involvement of the shared organs, and presence or absence of associated anomalies, with the worst prognosis in case of twins sharing liver and heart. Springer-Verlag, 2010 Conjoined twins nationallicence Prenatal diagnosis nationallicence Amniocentesis nationallicence Fetal karyotype nationallicence Necroscopy nationallicence Tonni Gabriele Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla, Reggio Emilia, Italy aut Ventura Alessandro Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla, Reggio Emilia, Italy aut Vito Ida Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla, Reggio Emilia, Italy aut Piana Daniela Division of Pathologic Anatomy, Arcispedale "Santa Maria Nuova”, Reggio Emilia, Italy aut Bonasoni Maria Division of Pathologic Anatomy, Arcispedale "Santa Maria Nuova”, Reggio Emilia, Italy aut De Felice Claudio Department of Neonatology, Policlinic Hospital "Le Scotte”, University of Siena, Siena, Italy aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 387-390 0932-0067 283:2<387 2011 283 404 https://doi.org/10.1007/s00404-010-1440-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1440-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tonni Gabriele Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla, Reggio Emilia, Italy aut NATIONALLICENCE 700 1- Ventura Alessandro Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla, Reggio Emilia, Italy aut NATIONALLICENCE 700 1- Vito Ida Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla, Reggio Emilia, Italy aut NATIONALLICENCE 700 1- Piana Daniela Division of Pathologic Anatomy, Arcispedale "Santa Maria Nuova”, Reggio Emilia, Italy aut NATIONALLICENCE 700 1- Bonasoni Maria Division of Pathologic Anatomy, Arcispedale "Santa Maria Nuova”, Reggio Emilia, Italy aut NATIONALLICENCE 700 1- De Felice Claudio Department of Neonatology, Policlinic Hospital "Le Scotte”, University of Siena, Siena, Italy aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 387-390 0932-0067 283:2<387 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer