caa a22 4500 445308915 CHVBK 20180317142622.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-009-1303-x doi (NATIONALLICENCE)springer-10.1007/s00404-009-1303-x Calprotectin, RAGE and TNF-α in hypertensive disorders in pregnancy: expression and significance [Elektronische Daten] [Chong Feng, Yongjian Tao, Tao Shang, Miao Yu] Objective: To investigate the expression of calprotectin, the receptor of advanced glycation end products (RAGE) and tumor necrosis factor-α (TNF-α) in hypertensive disorders in pregnancy as well as the significance of their expression. Methods: The research assessed levels of plasma calprotectin and TNF-α using the enzyme-linked immunosorbent assay, and expression of calprotectin, RAGE and TNF-α in placenta tissues using the immunohistochemistry streptavidin-peroxidase (S-P) method in 60 women with hypertensive disorders in pregnancy and 32 women with normal pregnancy (as the controls). Results: Compared with the control group, the levels of calprotectin, RAGE and TNF-α were elevated in plasma or placenta tissues in the group with hypertensive disorders in pregnancy, and were positively correlated with severity of hypertensive disorders in pregnancy. The levels of calprotectin were consistent with TNF-α in plasma and placenta tissues in the group with hypertensive disorders in pregnancy. Conclusion: Changes in calprotectin, RAGE and TNF-α levels in maternal serum and placental tissue correlate to the pathogenesis and disease progression of hypertensive disorders in pregnancy. Springer-Verlag, 2009 Calprotectin nationallicence RAGE nationallicence TNF-α nationallicence Preeclampsia nationallicence Inflammation nationallicence Feng Chong Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 110004, Shenyang, Liaoning, China aut Tao Yongjian Anshan Tiexi Hospital affiliated to Dalian Medical University, Anshan, China aut Shang Tao Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 110004, Shenyang, Liaoning, China aut Yu Miao Shenyang Pharmaceutical University, Shenyang, China aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 161-166 0932-0067 283:2<161 2011 283 404 https://doi.org/10.1007/s00404-009-1303-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-009-1303-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feng Chong Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 110004, Shenyang, Liaoning, China aut NATIONALLICENCE 700 1- Tao Yongjian Anshan Tiexi Hospital affiliated to Dalian Medical University, Anshan, China aut NATIONALLICENCE 700 1- Shang Tao Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 110004, Shenyang, Liaoning, China aut NATIONALLICENCE 700 1- Yu Miao Shenyang Pharmaceutical University, Shenyang, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 161-166 0932-0067 283:2<161 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer