caa a22 4500 44530894X CHVBK 20180317142622.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-009-1349-9 doi (NATIONALLICENCE)springer-10.1007/s00404-009-1349-9 Risks of pregnancy and birth in obese primiparous women: an analysis of German perinatal statistics [Elektronische Daten] [Volker Briese, Manfred Voigt, Josef Wisser, Ulrike Borchardt, Sebastian Straube] Purpose: To compare risks of pregnancy and birth in obese (body mass index, BMI≥30) and normal weight women (BMI 18.5-24.99) giving birth to their first child. Methods: We analysed data of 243,571 pregnancies in primiparous women from the German perinatal statistics of 1998-2000. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) for selected pregnancy and birth risks. ORs were adjusted for the confounding factors age, smoking status, single mother status, and maternal education. Results: Obesity during pregnancy is common in primiparous women (n=19,130; 7.9% of all cases) and it is significantly associated with a number of risks of pregnancy and birth, including diabetes [OR 3.71 (95% CI 2.93; 4.71); p<0.001], hypertension [OR 8.44 (7.91; 9.00); p<0.001], preecalmpsia/eclampsia [OR 6.72 (6.30; 7.17); p<0.001], intraamniotic infection [OR 2.33 (2.05; 2.64); p<0.001], birth weight ≥4,000g [OR 2.16 (2.05; 2.28); p<0.001], and an increased rate of Caesarean section [OR 2.23 (2.15; 2.30); p<0.001]. Some risks were less frequent in the obese such as cervical incompetence [OR 0.55 (0.48; 0.63); p<0.001] and preterm labour [OR 0.47 (0.43; 0.51); p<0.001]. Conclusions: Obesity during pregnancy is an important clinical problem in primiparous women because it is common and it is associated with a number of risks of pregnancy and birth. Because of these increased risks, obese women need special attention clinically during the course of their first pregnancy. Weight reduction before the first pregnancy is generally indicated in obese women to prevent the above-mentioned complications of pregnancy and birth. The Author(s), 2010 Body mass index nationallicence Parity nationallicence Diabetes nationallicence Hypertension nationallicence Preeclampsia nationallicence Briese Volker Department of Obstetrics and Gynaecology, University of Rostock, Rostock, Germany aut Voigt Manfred Institute for Perinatal Auxology, Klinikum Südstadt, Rostock, Germany aut Wisser Josef Department of Obstetrics and Gynaecology, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland aut Borchardt Ulrike Research Institute for the Biology of Farm Animals (FBN), Research Unit Genetics and Biometry, Dummerstorf, Germany aut Straube Sebastian Department of Occupational and Social Medicine, University of Göttingen, Göttingen, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 249-253 0932-0067 283:2<249 2011 283 404 https://doi.org/10.1007/s00404-009-1349-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-009-1349-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Briese Volker Department of Obstetrics and Gynaecology, University of Rostock, Rostock, Germany aut NATIONALLICENCE 700 1- Voigt Manfred Institute for Perinatal Auxology, Klinikum Südstadt, Rostock, Germany aut NATIONALLICENCE 700 1- Wisser Josef Department of Obstetrics and Gynaecology, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Borchardt Ulrike Research Institute for the Biology of Farm Animals (FBN), Research Unit Genetics and Biometry, Dummerstorf, Germany aut NATIONALLICENCE 700 1- Straube Sebastian Department of Occupational and Social Medicine, University of Göttingen, Göttingen, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 249-253 0932-0067 283:2<249 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer