caa a22 4500 445309008 CHVBK 20180317142622.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00404-010-1404-6 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1404-6 Combined positron emission tomography-computed tomography and tumor markers for detecting recurrent ovarian cancer [Elektronische Daten] [Hun-Shan Pan, Shiow-Lin Lee, Lee-Wen Huang, Yen-Kung Chen] Objective: To evaluate the accuracy of integrated FDG-PET/CT and tumor markers for the depiction of recurrent ovarian carcinoma. Methods: Patients with pathologically proven ovarian cancer, who underwent cytoreductive surgery and 3-6 cycles of adjuvant chemotherapy, were included in this study. They all underwent a thorough physical examination, tumor marker determination, and FDG-PET/CT imaging. The sensitivity, specificity, accuracy, and positive and negative predictive values for the tumor detection with PET/CT versus different tumor markers were performed in relation to the results at histological analysis after second-look surgery or clinical follow-up. Results: A total of 37 patients underwent FDG-PET/CT scans. Among them, 22 patients underwent exploratory laparotomy and 15 had diagnostic laparoscopy. Overall, 24 patients were documented to have ovarian cancer recurrence after second operation. FDG-PET/CT had sensitivity, specificity, accuracy, and positive and negative predictive values of 100, 85, 94, 92, and 100%, respectively. Conclusion: Our study has shown that PET/CT is a sensitive tool to assist in the early identification and recurrent ovarian cancer, amenable to secondary cytoreduction. Springer-Verlag, 2010 Serum tumor marker nationallicence Positron emission tomography-computed tomography nationallicence Recurrent ovarian cancer nationallicence Pan Hun-Shan Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, No 95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan aut Lee Shiow-Lin Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, No 95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan aut Huang Lee-Wen Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, No 95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan aut Chen Yen-Kung Department of Radiology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan aut Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 335-341 0932-0067 283:2<335 2011 283 404 https://doi.org/10.1007/s00404-010-1404-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1404-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pan Hun-Shan Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, No 95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lee Shiow-Lin Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, No 95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan aut NATIONALLICENCE 700 1- Huang Lee-Wen Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, No 95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen Yen-Kung Department of Radiology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 283/2(2011-02-01), 335-341 0932-0067 283:2<335 2011 283 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer