caa a22 4500 445309067 CHVBK 20180317142623.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-011-1850-9 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1850-9 Epidemiology of vulvar and vaginal cancer in Germany [Elektronische Daten] [C. Dittmer, A. Katalinic, C. Mundhenke, M. Thill, D. Fischer] Objective: Vulvar and vaginal cancers are rare diseases with an incidence rate that increases with age. At present, epidemiological data are rather scarce. This review article provides an epidemiologic overview of these diseases, focussing on recent German data. Methods: This review article summarizes the information currently available in order to offer an epidemiologic overview. Results: The statistic incidence of vulvar carcinoma has been calculated between 2 and 7 cases per 100,000 women, and that of vaginal carcinoma 0.6-1.0 cases per 100,000 women. These incidence rates, especially concerning intraepithelial neoplasm, have increased heavily since the 1970s. The mean age of vulvar cancer affection is 72years, and 74years for vaginal carcinoma. In the case of women below the age of 50, cancer tends to be HPV-associated which implies a coincidence of about 20% for cervical and anal cancer. Various pathological mechanisms are the cause for women above the age of 50. Conclusions: Due to a change in sexual behavior and an increased rate of HPV infection among younger women, increased incidence of both diseases has to be expected. The age-standardized mortality rate of vulvar carcinoma in Europe is stated at 0.7/100,000 women, and that of vaginal carcinoma at 0.4/100.000 women. To what extent the HPV-vaccination affects incidence and mortality rates is continually being observed. Springer-Verlag, 2011 Epidemiology nationallicence Vulvar cancer nationallicence Vaginal cancer nationallicence Incidence nationallicence Mortality nationallicence Dittmer C. Department of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Katalinic A. Institute of Cancer Epidemiology, University of Lübeck, Beckergrube 43-47, 23552, Lübeck, Germany aut Mundhenke C. Deparment of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany aut Thill M. Department of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Fischer D. Department of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 169-174 0932-0067 284:1<169 2011 284 404 https://doi.org/10.1007/s00404-011-1850-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1850-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dittmer C. Department of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Katalinic A. Institute of Cancer Epidemiology, University of Lübeck, Beckergrube 43-47, 23552, Lübeck, Germany aut NATIONALLICENCE 700 1- Mundhenke C. Deparment of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany aut NATIONALLICENCE 700 1- Thill M. Department of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Fischer D. Department of Obstetrics and Gynaecology, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 169-174 0932-0067 284:1<169 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer