caa a22 4500 445309113 CHVBK 20180317142623.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-010-1596-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1596-9 Bone mineral density changes in pregnancies with gestational hypertension: a longitudinal study using quantitative ultrasound measurements [Elektronische Daten] [William To, Margaret Wong] Objective: To compare the maternal bone mineral density (BMD) changes in gestational hypertensive and normotensive pregnancies using quantitative ultrasound. Methods: Consecutive patients were recruited from a general obstetric clinic over a period of 9months. BMD measurements were performed at the os calcis in early pregnancy before 20weeks and in the late third trimester after 36weeks, using a Hologic Sahara Clinical Bone Sonometer system. These patients were followed up in accordance with standard antenatal protocol. The diagnosis of gestational hypertension (GH) was made based on a standard institutional protocol. The changes in BMD from early to late pregnancy were compared between those with/without GH. Results: A total of 450 patients with complete data were analyzed. The overall incidence of GH was 4.8% (n=22), of which 1.7% (n=8) fulfilled the definitions of severe pre-eclampsia. A mean BMD loss of 0.0256g/cm2 (around 4.5% of early pregnancy BMD) was demonstrable from early to late gestation. The hypertensive group has marginally higher mean BMD loss as compared to the normotensive group (0.052 vs. 0.037g/cm2; P=0.037). However, regression analysis models showed that early pregnancy BMD values, early pregnancy fat percentage and fat accumulation in pregnancy were significant factors affecting BMD loss during pregnancy, while GH was not in the equations. Conclusion: The development of gestational hypertensive disorders apparently does not have any significant impact on BMD changes during pregnancy. The Author(s), 2010 Bone mineral density nationallicence Gestational hypertension nationallicence Quantitative ultrasound nationallicence To William Department of Obstetrics and Gynaecology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong aut Wong Margaret Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 39-44 0932-0067 284:1<39 2011 284 404 https://doi.org/10.1007/s00404-010-1596-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1596-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- To William Department of Obstetrics and Gynaecology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong aut NATIONALLICENCE 700 1- Wong Margaret Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 39-44 0932-0067 284:1<39 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer