caa a22 4500 445309229 CHVBK 20180317142623.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-010-1540-z doi (NATIONALLICENCE)springer-10.1007/s00404-010-1540-z Pregnancy outcome in women with autoimmune hepatitis [Elektronische Daten] [Neelam Aggarwal, Seema Chopra, Vanita Suri, Pooja Sikka, R. Dhiman, Yogesh Chawla] Introduction: Autoimmune hepatitis (AIH) is a chronic disease of unknown cause, characterized by progressive hepatocellular inflammation and necrosis, frequently leading to cirrhosis. AIH usually affects young women and may influence fertility and pregnancy in them. Nearly 200 pregnancies have been reported so far in the world literature in women with AIH, and no definite guidelines have been established. We hereby report our experience of four pregnancies in women with definite diagnosis of AIH. Materials and methods: We studied the maternal and perinatal outcome of four women with AIH. The medical history was recorded in detail. The pregnancies were allowed to continue with careful fetal and maternal surveillance. Antenatal complications, disease course during pregnancy, intrapartum maternal fetal events, mode of delivery, and perinatal outcome were noted. Results: All four patients had preterm labor: three had vaginal delivery and cesarean was done in one due to breech presentation with preterm rupture of membranes. All the infants were live born with birth weight appropriate for gestational age and were born with good Apgar scores and no congenital malformation. The incidence of post partum hemorrhage was 25% and so was the maternal mortality. Conclusion: Successful pregnancy outcome in patients with well-controlled AIH seems to be a realistic expectation with careful monitoring jointly by the Obstetricians and Hepatologists, especially in the post partum period. Steroids seem to be the safe alternative as immunosuppressant therapy although azathioprine has also been seen to be generally safe for mother or baby. Springer-Verlag, 2010 Autoimmune nationallicence Pregnancy nationallicence Immunosuppressants nationallicence Cirrhosis nationallicence Perinatal outcome nationallicence Aggarwal Neelam Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Chopra Seema Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Suri Vanita Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Sikka Pooja Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Dhiman R. Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Chawla Yogesh Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 19-23 0932-0067 284:1<19 2011 284 404 https://doi.org/10.1007/s00404-010-1540-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1540-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aggarwal Neelam Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Chopra Seema Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Suri Vanita Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Sikka Pooja Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Dhiman R. Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Chawla Yogesh Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 19-23 0932-0067 284:1<19 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer