caa a22 4500 445309326 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-010-1610-2 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1610-2 High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma [Elektronische Daten] [Xiao-Ling Gan, Jin-Ke Li, Ting-He Yu, Yi Zhang, Li-Na Hu] Purposes: Uterine cervical carcinosarcoma (CS) is very rare. To date, only 40 cases have been reported. It seems to have a more aggressive clinical behavior than does cervical squamous cell carcinoma (SCC). The purposes of our study were to characterize the clinicopathologic characteristics and human papillomavirus (HPV) status of the rare tumor and to analyze the molecular features in cervical CS that may account for its aggressive behavior. Methods: Three patients were diagnosed with uterine cervical CS at West China Second Hospital of Sichuan University between 1995 and 2009. Data were retrospectively analyzed from available charts and pathological reports. Twelve patients with FIGO stage Ib-IIa cervical SCC were enrolled as the controls, and the expression profiling of p53, Ki-67, bcl-2, survivin and apoptosis index between cervical CS and SCC was compared. Immunohistochemical and apoptosis results were scored separately for the carcinomatous and sarcomatous components. Results: All three patients were shown to be negative for HPV infection by Hybribio HPV genoarray assay. Expression of p53 was observed in one patient in both carcinomatous and sarcomatous components in a similar proportion; in contrast, the Ki67, bcl-2 and survivin expressions were higher in carcinomatous components than in sarcomatous components in all three cases. Compared to cervical SCC, stronger immunostaining for bcl-2, survivin and lower apoptosis was observed in cervical CS. Conclusions: Cervical CS is a peculiar tumor with many different clinicopathologic characteristics from cervical SCC. Dysregulation of apoptosis may confer tumor cells of cervical CS with survival and growth advantages, and thereby facilitate the aggressive behavior of cervical CS. Springer-Verlag, 2010 Apoptosis nationallicence Cervical carcinosarcoma nationallicence bcl-2 nationallicence Survivin nationallicence Human papillomavirus nationallicence Gan Xiao-Ling Departments of Gynecology and Obstetrics, West China Secondary Hospital, Sichuan University, 20 Renmingnan Road, 610041, Chengdu, Sichuan, People's Republic of China aut Li Jin-Ke Departments of Gynecology and Obstetrics, West China Secondary Hospital, Sichuan University, 20 Renmingnan Road, 610041, Chengdu, Sichuan, People's Republic of China aut Yu Ting-He Laboratory of Biomedical Ultrasonics and Gynecologic Cancers, West China Institutes of Women and Children's Health, Sichuan University, Chengdu, Sichuan, People's Republic of China aut Zhang Yi Laboratory of Biomedical Ultrasonics and Gynecologic Cancers, West China Institutes of Women and Children's Health, Sichuan University, Chengdu, Sichuan, People's Republic of China aut Hu Li-Na Departments of Gynecology and Obstetrics, West China Secondary Hospital, Sichuan University, 20 Renmingnan Road, 610041, Chengdu, Sichuan, People's Republic of China aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 175-181 0932-0067 284:1<175 2011 284 404 https://doi.org/10.1007/s00404-010-1610-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1610-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gan Xiao-Ling Departments of Gynecology and Obstetrics, West China Secondary Hospital, Sichuan University, 20 Renmingnan Road, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Li Jin-Ke Departments of Gynecology and Obstetrics, West China Secondary Hospital, Sichuan University, 20 Renmingnan Road, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Yu Ting-He Laboratory of Biomedical Ultrasonics and Gynecologic Cancers, West China Institutes of Women and Children's Health, Sichuan University, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Yi Laboratory of Biomedical Ultrasonics and Gynecologic Cancers, West China Institutes of Women and Children's Health, Sichuan University, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Hu Li-Na Departments of Gynecology and Obstetrics, West China Secondary Hospital, Sichuan University, 20 Renmingnan Road, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 175-181 0932-0067 284:1<175 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer