caa a22 4500 445309342 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-010-1605-z doi (NATIONALLICENCE)springer-10.1007/s00404-010-1605-z The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer [Elektronische Daten] [Stephen Koh, K. Razvi, Y. Chan, K. Narasimhan, A. Ilancheran, J. Low, M. Choolani] Purpose: To assess known cancer biomarkers CA-125, human tissue kallikreins KLK6 and KLK10, hemostatic markers and age with 5-year survival outcome from epithelial ovarian cancer. Methods: Forty-one benign cyst cohorts and 83 patients diagnosed with ovarian cancer were recruited. The following assays were performed: fibrinogen, vWF antigen, d-dimer, ATIII activity, tPA, PAI-1, uPAR, KLK6, KLK10 and CA-125. Follow-up visits of cancer patients of more than 60months were noted. Data between those who survived past 60months and mortality from cancer were analyzed. Results: Only 24 patients lived past 60months, and 31 died (advanced stage n=27). Those living past 60months were significantly older and associated with similar pre-operative levels seen in benign cyst cohorts especially for KLK6, fibrinogen, vWF, AT levels despite upregulation of d-dimer, CA-125 and KLK10. Ovarian cancer cohorts living past 60months were younger than those who died within 12months (n=12). Mortality within 12months was associated with older age, upregulation of KLK6, fibrinogen, d-dimer, vWF, tPA antigen and reduced ATIII levels. Similarly, mortality within 36months of disease showed older age with upregulation of CA-125, KLK6 d-dimer vWF antigen and tPA antigen levels. Late stage cancer (III/IV) showed upregulated CA-125, KLK6, KLK10, d-dimer and reduced AT compared to early stage cancer (I/II). The 5-year survival rate for early cancer was 80%, advanced 22.9% and overall 5-year survival rate was 43.6%. Conclusion: Older age together with the novel biomarkers studied and their association with adverse outcome from epithelial ovarian cancer was seen especially within 12 and 36months of disease. Those who lived past 60months of disease showed similar pre-operative levels seen in benign cyst cohorts despite elevated d-dimer, CA125 and KLK 10. An enlarged study is needed to confirm these findings. Springer-Verlag, 2010 Age nationallicence KLK6 nationallicence KLK10 nationallicence Hemostatic markers nationallicence Ovarian cancer nationallicence Koh Stephen Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut Razvi K. Southend University Hospital, NHS Foundation Trust, Essex, UK aut Chan Y. Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut Narasimhan K. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut Ilancheran A. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut Low J. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut Choolani M. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 183-190 0932-0067 284:1<183 2011 284 404 https://doi.org/10.1007/s00404-010-1605-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1605-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koh Stephen Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut NATIONALLICENCE 700 1- Razvi K. Southend University Hospital, NHS Foundation Trust, Essex, UK aut NATIONALLICENCE 700 1- Chan Y. Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut NATIONALLICENCE 700 1- Narasimhan K. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut NATIONALLICENCE 700 1- Ilancheran A. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut NATIONALLICENCE 700 1- Low J. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut NATIONALLICENCE 700 1- Choolani M. Department of Obstetrics and Gynaecology, National University Health Systems (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 183-190 0932-0067 284:1<183 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer