caa a22 4500 445309393 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-011-1917-7 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1917-7 Changes in prepregnancy body mass index between pregnancies and risk of gestational and type 2 diabetes [Elektronische Daten] [Valerie Whiteman, Muktar Aliyu, Euna August, Cheri McIntosh, Jingyi Duan, Amina Alio, Hamisu Salihu] Introduction: We investigated whether changes in interpregnancy body mass index (BMI) influence the risk of gestational and type 2 diabetes among a cohort of women with two consecutive live, singleton births of 20-44weeks gestation (n=232,272). Methods: Logistic regression models were used to examine the risk for development of gestational or type 2 diabetes during the second pregnancy. Mothers with normal weight for both pregnancies (normal-normal) served as the referent group. Results: Across all BMI categories, mothers with significant weight gain (i.e., moving from a lower BMI category into a higher category) had an increased risk for the development of diabetes. Mothers who moved from normal prepregnancy weight (BMI=18.5-24.9kg/m2) in the first pregnancy to obese prepregnancy weight (BMI≥30.0kg/m2) in the second pregnancy showed the greatest increment in risk. These mothers exhibited a threefold risk for developing diabetes (OR=3.21, 95% CI 2.76-3.73). Mothers who maintained their interpregnancy BMI weight category or who moved to a lower BMI category had reduced risk for gestational and type 2 diabetes. The risk associated with mothers who moved to a lower BMI category was approximately half that of the normal-normal BMI category. Conclusion: Interpregnancy weight gain is associated with a dose-response increase in risk of diabetes. Establishing a normal interpregnancy BMI may reduce the risk of diabetes. Springer-Verlag, 2011 Diabetes nationallicence Interpregnancy weight gain nationallicence Singletons nationallicence Whiteman Valerie Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, Tampa, FL, USA aut Aliyu Muktar Department of Preventive Medicine and Institute for Global Health, Vanderbilt University, Nashville, TN, USA aut August Euna Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FL, USA aut McIntosh Cheri Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs, MDC56, 33612, Tampa, FL, USA aut Duan Jingyi Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs, MDC56, 33612, Tampa, FL, USA aut Alio Amina Department of Community and Preventive Medicine, University of Rochester, Rochester, USA aut Salihu Hamisu Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, Tampa, FL, USA aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 235-240 0932-0067 284:1<235 2011 284 404 https://doi.org/10.1007/s00404-011-1917-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1917-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Whiteman Valerie Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 700 1- Aliyu Muktar Department of Preventive Medicine and Institute for Global Health, Vanderbilt University, Nashville, TN, USA aut NATIONALLICENCE 700 1- August Euna Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 700 1- McIntosh Cheri Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs, MDC56, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Duan Jingyi Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs, MDC56, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Alio Amina Department of Community and Preventive Medicine, University of Rochester, Rochester, USA aut NATIONALLICENCE 700 1- Salihu Hamisu Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 235-240 0932-0067 284:1<235 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer