caa a22 4500 445309415 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-010-1611-1 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1611-1 Factors associated with recurrence of cervical intraepithelial neoplasia after conization in HIV-infected and noninfected women [Elektronische Daten] [Claudia Lodi, Márcia Michelin, Maria Lima, Nara Teixeira, Sheila Adad, Eddie Murta, Victor Melo] Purpose: To identify risk factors associated with recurrence of cervical intraepithelial neoplasia (CIN) following loop electrosurgical excision procedures in women with and without human immunodeficiency virus (HIV). Methods: A total of 33 patients with recurrent CIN and 105 without recurrence were contrasted using a nested case-control design. The patients were enrolled between 1999 and 2004. Recurrence diagnosis was established after conization, and tissues were fixed in formalin and embedded in paraffin. Polymerase chain reaction was used to detect the human papillomavirus genome (HPV DNA) types 6, 11, 16, 18, 31, 33, and 35. Statistical analysis was performed using χ2 test with Yates correction and the Fisher's exact test for comparison of categorical variables. Multivariate analysis was carried out using logistic regression models. Results: Human immunodeficiency virus infection (p=0.001), glandular involvement (p=0.000), and compromised margins (p=0.02) were significantly associated with CIN recurrence. HPV DNA was positive in 57.6% of patients with CIN recurrence. High-risk HPV subtypes were detected in most cases but were not associated with recurrence (p=0.27). In multivariate analysis, HIV infection and glandular involvement were independently associated with CIN recurrence. Conclusions: Human immunodeficiency virus infection and glandular involvement are associated with CIN recurrence. Springer-Verlag, 2010 Cervical intraepithelial neoplasia nationallicence Human immunodeficiency virus nationallicence Loop electrosurgical excision procedure nationallicence Recurrence nationallicence Human papillomavirus nationallicence Lodi Claudia Medical Science School of Minas Gerais, Belo Horizonte, Brazil aut Michelin Márcia Instituto de Pesquisa em Oncologia (Research Institute of Oncology), Federal University of Triangulo Mineiro, Uberaba, Brazil aut Lima Maria Serviço de Referencia em Patologia Cervical (Reference Service in Cervical Pathology), PAM Sagrada Família, Belo Horizonte, Brazil aut Teixeira Nara Prefeitura Municipal (Municipal Government), Belo Horizonte, Brazil aut Adad Sheila Instituto de Pesquisa em Oncologia (Research Institute of Oncology), Federal University of Triangulo Mineiro, Uberaba, Brazil aut Murta Eddie Instituto de Pesquisa em Oncologia (Research Institute of Oncology), Federal University of Triangulo Mineiro, Uberaba, Brazil aut Melo Victor School of Medicine, Federal University of Minas Gerais, Av Alfredo Balena 190, 4th floor, 30130-100, Belo Horizonte, MG, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 191-197 0932-0067 284:1<191 2011 284 404 https://doi.org/10.1007/s00404-010-1611-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1611-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lodi Claudia Medical Science School of Minas Gerais, Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Michelin Márcia Instituto de Pesquisa em Oncologia (Research Institute of Oncology), Federal University of Triangulo Mineiro, Uberaba, Brazil aut NATIONALLICENCE 700 1- Lima Maria Serviço de Referencia em Patologia Cervical (Reference Service in Cervical Pathology), PAM Sagrada Família, Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Teixeira Nara Prefeitura Municipal (Municipal Government), Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Adad Sheila Instituto de Pesquisa em Oncologia (Research Institute of Oncology), Federal University of Triangulo Mineiro, Uberaba, Brazil aut NATIONALLICENCE 700 1- Murta Eddie Instituto de Pesquisa em Oncologia (Research Institute of Oncology), Federal University of Triangulo Mineiro, Uberaba, Brazil aut NATIONALLICENCE 700 1- Melo Victor School of Medicine, Federal University of Minas Gerais, Av Alfredo Balena 190, 4th floor, 30130-100, Belo Horizonte, MG, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 191-197 0932-0067 284:1<191 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer