caa a22 4500 445309431 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00404-010-1650-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1650-7 Human papilloma virus persistence and neopterin, folate and homocysteine levels in cervical dysplasias [Elektronische Daten] [Faruk Abike, Ayse Engin, İlkkan Dunder, Omer Tapisiz, Canan Aslan, Lale Kutluay] Objective: To investigate the relationship between human papilloma virus (HPV) infection persistence and serum folate, vitamin B12, homocysteine, neopterin levels in cervical dysplasia. Study design: Through the years 2007-2008, 122 women who have admitted to Gynecology Clinic were evaluated for cervical cytology, demographical characteristics, HPV infection, serum folate, vitamin B12, homocysteine, albumin, and neopterin levels. Results: Considering all the cases, the highest percentage of the HPV-infected patients was in high-grade squamous intraepithelial lesion (HSIL) group (83%, n=25). The serum folate levels in all patient groups [HSIL 10.0±0.4ng/ml, low-grade squamous intraepithelial lesion (LSIL) 10.6±0.5ng/ml, atypical squamous cells-undetermined significance (ASCUS) 11.1±0.8ng/ml] were lower than control group (11.9±0.5ng/ml; p<0.05). The vitamin B12 levels were not significantly altered in any of the patient groups. The serum homocysteine levels in all patient groups (HSIL 10.4±0.5Umol/l, LSIL 10.1±0.5Umol/l, ASCUS 10.5±0.7Umol/l) were higher than the control group (7.9±0.5Umol/l; p<0.05). The neopterin levels of HSIL group (1.0±0.2ng/ml) were lower than the control group (1.5±0.2ng/ml; p<0.05). The serum neopterin concentrations of HSIL with HPV group (0.6±0.1ng/ml) were significantly lower than HSIL without HPV (2.4±0.9ng/ml) and other study groups (p<0.05). The serum homocysteine levels of HSIL HPV(+) group and LSIL HPV(+) were higher than control group (p<0.05). The serum albumin levels of HSIL with HPV group are lower than control and other groups (p<0.05). In all cervical dysplasia groups, folate levels in patients infected with HPV are lower than in HPV(−) patients (p<0.05). Conclusions: Folic acid deficiency could be caused by insufficient cellular immunity. In case of folate deficiency, the predisposition of HPV infection persistency and progression of cervical dysplasia increase. The fact that neopterin is a strong cellular immunity marker and it was detected in patients with HPV persistence and cervical dysplasia in lower levels shows that these patients may have relatively insufficient immune system. In order for dysplasia progression to be prevented, folate fortification on diets may be advised to HPV-infected women. Springer-Verlag, 2010 HPV infection nationallicence Cervical dysplasia nationallicence Folate nationallicence Homocysteine nationallicence Neopterin nationallicence Abike Faruk Department of Gynecological Oncology, Bayindir Hospital, Sogutozu, 06200, Ankara, Turkey aut Engin Ayse Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey aut Dunder İlkkan Department of Gynecological Oncology, Faculty of Medicine, Bilim University, Istanbul, Turkey aut Tapisiz Omer Dr Zekai Tahir Burak Women Health and Research Hospital, Ankara, Turkey aut Aslan Canan Institute of Health Sciences, Bilim University, Istanbul, Turkey aut Kutluay Lale Department of Pathology, Bayindir Hospital, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 209-214 0932-0067 284:1<209 2011 284 404 https://doi.org/10.1007/s00404-010-1650-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1650-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abike Faruk Department of Gynecological Oncology, Bayindir Hospital, Sogutozu, 06200, Ankara, Turkey aut NATIONALLICENCE 700 1- Engin Ayse Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey aut NATIONALLICENCE 700 1- Dunder İlkkan Department of Gynecological Oncology, Faculty of Medicine, Bilim University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Tapisiz Omer Dr Zekai Tahir Burak Women Health and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Aslan Canan Institute of Health Sciences, Bilim University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kutluay Lale Department of Pathology, Bayindir Hospital, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/1(2011-07-01), 209-214 0932-0067 284:1<209 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer