caa a22 4500 445309458 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-010-1827-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1827-0 The effect of low dose human chorionic gonadotropin on follicular response and oocyte maturation in PCOS patients undergoing IVF cycles: a randomized clinical trial of efficacy and safety [Elektronische Daten] [Mahnaz Ashrafi, Kiandokht Kiani, Afsaneh Ghasemi, Fatemeh Rastegar, Maryam Nabavi] Purpose: To compare the efficacy of two regimens of low dose human chorionic gonadotropin (hCG) on follicular response and oocyte maturation in women with polycystic ovarian syndrome (PCOS). Methods: Ninety women with PCOS who underwent assisted reproduction were eligible for this controlled, prospective, randomized study. Our trial was performed at Royan Institute Reproductive Research Center over a 24-month period. Ovarian stimulation in all groups was initiated with recombinant FSH, 150IU daily. The dose and duration of FSH treatment were adjusted by monitoring follicular development with ultrasound and estradiol levels. Patients were randomized using a block randomization technique which assigned them to three groups: group A (control group) continued r-FSH until oocyte retrieval. In group B, r-FSH was reduced to 75IU once the lead follicle reached 14mm in mean diameter and low dose hCG (100IU/day) was initiated. In group C, r-FSH was discontinued and low dose hCG (200IU/day) was begun when the lead follicle reached 14mm in mean diameter. The main outcome measure was follicular response and oocyte maturation. Results: As compared to the FSH only group, groups which were given low dose hCG had lower gonadotropin consumption and fewer immature oocytes than the control group. No women in the low dose hCG groups developed severe ovarian hyper-stimulation syndrome. Fertilization, implantation and pregnancy rates were similar in the three groups. Conclusions: A combination of FSH and low dose hCG improved oocyte maturity and preserved outcomes with improved safety and lowered cost. Springer-Verlag, 2011 Low dose hCG nationallicence Polycystic ovarian syndrome nationallicence Follicular response nationallicence Oocyte maturation nationallicence Ashrafi Mahnaz Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Number 12, East Hafez Avenue, Bani Hashem Street, Resalat Highway, P.O. Box 19395-4644, Tehran, Iran aut Kiani Kiandokht Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Number 12, East Hafez Avenue, Bani Hashem Street, Resalat Highway, P.O. Box 19395-4644, Tehran, Iran aut Ghasemi Afsaneh Department of Obstetrics and Gynecology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran aut Rastegar Fatemeh Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Number 12, East Hafez Avenue, Bani Hashem Street, Resalat Highway, P.O. Box 19395-4644, Tehran, Iran aut Nabavi Maryam Department of Epidemiology and Reproductive Health, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1431-1438 0932-0067 284:6<1431 2011 284 404 https://doi.org/10.1007/s00404-010-1827-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1827-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ashrafi Mahnaz Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Number 12, East Hafez Avenue, Bani Hashem Street, Resalat Highway, P.O. Box 19395-4644, Tehran, Iran aut NATIONALLICENCE 700 1- Kiani Kiandokht Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Number 12, East Hafez Avenue, Bani Hashem Street, Resalat Highway, P.O. Box 19395-4644, Tehran, Iran aut NATIONALLICENCE 700 1- Ghasemi Afsaneh Department of Obstetrics and Gynecology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Rastegar Fatemeh Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Number 12, East Hafez Avenue, Bani Hashem Street, Resalat Highway, P.O. Box 19395-4644, Tehran, Iran aut NATIONALLICENCE 700 1- Nabavi Maryam Department of Epidemiology and Reproductive Health, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1431-1438 0932-0067 284:6<1431 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer