caa a22 4500 445309563 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1865-2 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1865-2 Evaluation of oxidative stress markers in first trimester for assessment of preeclampsia risk [Elektronische Daten] [Habibe Genc, Hafize Uzun, Ali Benian, Gönül Simsek, Remise Gelisgen, Rıza Madazli, Onur Güralp] Aim: The aim of this study is to determine the predictive values of oxidative stress markers and antioxidants in the development of preeclampsia between 10-14 and also at 20-24weeks of gestation, after the completion of vascular transformation. Materials and methods: Levels of oxidative stress parameters such as malondialdehyde (MDA), lipidhydroperoxide (LHP) and prostaglandin F2α (PGF2α), oxidized LDL (oxLDL), and antioxidant status parameters such as paraoxonase 1 (PON1), superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels were measured and compared in 21 preeclamptic and 24 healthy pregnant women. Results: In preeclamptic women, both between 10-14 and also at 20-24weeks of gestation the levels of oxLDL, MDA and PGF2α were significantly higher (P<0.001, P<0.001, respectively), PON1, SOD and TAC were significantly lower (P<0.01, P<0.001, P<0.05, respectively) compared to healthy pregnant women; yet there was no significant difference in LHP levels. Conclusion: Increased levels of serum MDA and PGF2α, low levels of SOD and PON1 activity, in 10-14 GW may have been associated with preeclampsia etiology. High levels of MDA and PGF2α indicate that the oxidative damage is present well before the clinical symptoms occur. A panel of oxidative stress markers such as MDA and PGF2α in maternal blood can predict the development of preeclampsia long before clinical onset. Springer-Verlag, 2011 Preeclampsia nationallicence Malondialdehyde nationallicence Lipidhydroperoxide nationallicence Prostaglandin F2α nationallicence Oxidized LDL nationallicence Paraoxonase1 nationallicence Superoxide dismutase nationallicence Total antioxidant capacity nationallicence Genc Habibe Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303, Istanbul, Turkey aut Uzun Hafize Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303, Istanbul, Turkey aut Benian Ali Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut Simsek Gönül Department of Physiology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut Gelisgen Remise Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303, Istanbul, Turkey aut Madazli Rıza Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut Güralp Onur Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1367-1373 0932-0067 284:6<1367 2011 284 404 https://doi.org/10.1007/s00404-011-1865-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1865-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Genc Habibe Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303, Istanbul, Turkey aut NATIONALLICENCE 700 1- Uzun Hafize Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303, Istanbul, Turkey aut NATIONALLICENCE 700 1- Benian Ali Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut NATIONALLICENCE 700 1- Simsek Gönül Department of Physiology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut NATIONALLICENCE 700 1- Gelisgen Remise Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, 34303, Istanbul, Turkey aut NATIONALLICENCE 700 1- Madazli Rıza Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut NATIONALLICENCE 700 1- Güralp Onur Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1367-1373 0932-0067 284:6<1367 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer