caa a22 4500 445309598 CHVBK 20180317142624.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1886-x doi (NATIONALLICENCE)springer-10.1007/s00404-011-1886-x Quality of life and adverse events after radiotherapy in gynecologic cancer survivors: a cohort study [Elektronische Daten] [Ana Vaz, Délio Conde, Lúcia Costa-Paiva, Sirlei Morais, Sérgio Esteves, Aarão Pinto-Neto] Purpose: To evaluate quality of life (QOL) in gynecologic cancer survivors after radiotherapy (RT), investigate the frequency of adverse events and demonstrate an association between these symptoms and QOL. Methods: A prospective cohort study of 95 women aged 21-75years undergoing RT for gynecologic cancer was carried out. QOL was assessed by the WHOQOL-BREF before, at 4months, 1year and 3years after RT and adverse events were evaluated following RT by the (CTCAE) v 3.0 scale. QOL scores were assessed by the Wilcoxon signed rank test over time. Multiple linear regression analysis was used to identify predictors of QOL. Results: The most frequent adverse events were pain (64.2%) and dyspareunia (45.9%). A significant increase in QOL scores was observed in the psychological domain, general health and overall QOL. Pain was negatively associated with the physical, psychological and social relationship domains (p<0.01); dyspareunia with the physical and social relationship (p<0.01); decreased sexual interest with the psychological (p<0.01). Higher family income was positively associated with the psychological domain and general health (p<0.01). Conclusions: Results suggested that QOL improved after RT in women with gynecologic cancer. Adverse events, such as pain, dyspareunia and decreased sexual interest had a negative impact on QOL. Springer-Verlag, 2011 Gynecologic cancer nationallicence Quality of life nationallicence Adverse events nationallicence Radiotherapy nationallicence Vaz Ana Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut Conde Délio Gynecology Service, Hospital Materno Infantil, PO Box 6111, Goiânia, Brazil aut Costa-Paiva Lúcia Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut Morais Sirlei Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut Esteves Sérgio Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut Pinto-Neto Aarão Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1523-1531 0932-0067 284:6<1523 2011 284 404 https://doi.org/10.1007/s00404-011-1886-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1886-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vaz Ana Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut NATIONALLICENCE 700 1- Conde Délio Gynecology Service, Hospital Materno Infantil, PO Box 6111, Goiânia, Brazil aut NATIONALLICENCE 700 1- Costa-Paiva Lúcia Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut NATIONALLICENCE 700 1- Morais Sirlei Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut NATIONALLICENCE 700 1- Esteves Sérgio Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut NATIONALLICENCE 700 1- Pinto-Neto Aarão Department of Gynecology and Obstetrics, Universidade Estadual de Campinas. Rua Alexander Fleeming, 101, Cidade Universitária ‘‘Zeferino Vaz'', 13083-970, Campinas, SP, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1523-1531 0932-0067 284:6<1523 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 445309598 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer