caa a22 4500 445309628 CHVBK 20180317142625.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1860-7 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1860-7 The effects of preoperative intravenous acetaminophen in patients undergoing abdominal hysterectomy [Elektronische Daten] [Young-Eun Moon, Yoon-Ki Lee, Jaemin Lee, Dong-Eon Moon] Purpose: Although intravenous acetaminophen is commonly used for the management of postoperative pain, very limited evidence supports the usefulness of preoperative administration. The aim of this study was to determine the analgesic effect of preoperative acetaminophen on opioid consumption, pain scores, and side effects in patients receiving an elective abdominal hysterectomy. Methods: A randomized, double-blinded, placebo-controlled clinical trial was performed in 76 women undergoing abdominal hysterectomy. Patients received either acetaminophen 2g (group A) or placebo (group C) intravenously 30min before surgery under general anesthesia. Postoperative pain was treated with patient-controlled intravenous hydromorphone 0.2mg bolus. Hydromorphone consumption, pain scores during rest and movement, and any adverse effects were recorded at 1, 2, 6, 12, and 24h after the operation. Results: Overall hydromorphone consumption was significantly lower in group A compared with group C at all the time points (P=0.013). The total 24-h hydromorphone consumption was reduced by 30% in group A. There was no significant difference in pain scores. The incidence of postoperative nausea and vomiting after the operation were significantly lower in group A than in group C (P<0.05). Conclusions: Premedication with acetaminophen reduced hydromorphone consumption and opioid-related side effect in patients undergoing abdominal hysterectomy, but did not significantly reduce pain intensity. Springer-Verlag, 2011 Acetaminophen nationallicence Opioid-sparing effect nationallicence Postoperative pain nationallicence Premedication nationallicence Moon Young-Eun Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut Lee Yoon-Ki Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut Lee Jaemin Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut Moon Dong-Eon Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1455-1460 0932-0067 284:6<1455 2011 284 404 https://doi.org/10.1007/s00404-011-1860-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1860-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moon Young-Eun Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Yoon-Ki Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Jaemin Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut NATIONALLICENCE 700 1- Moon Dong-Eon Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic Medical College, Banpo-dong, Seoul, South Korea aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1455-1460 0932-0067 284:6<1455 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer