caa a22 4500 445309660 CHVBK 20180317142625.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1997-4 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1997-4 Recombinant FSH versus clomiphene citrate for ovarian stimulation in couples with unexplained infertility and male subfertility undergoing intrauterine insemination: a randomized trial [Elektronische Daten] [Bulent Berker, Korhan Kahraman, Salih Taskin, Yavuz Sukur, Murat Sonmezer, Cem Atabekoglu] Purpose: To compare the efficacy of clomiphene citrate (CC) and recombinant FSH (rFSH) protocols in ovarian stimulation (OS)/intrauterine insemination (IUI) cycles for couples with unexplained infertility or male subfertility. Methods: One hundred and eighty-nine patients with unexplained or male subfertility were randomized to treatment with 100mg/day CC for 5days (93 patients) or rFSH with starting dose of 75-100IU daily (96 patients). The main outcome measurement was ongoing pregnancy rate (OPR). Results: The number of preovulatory (≥17mm) follicles on the day of hCG administration was significantly greater in the rFSH group than in the CC group (1.7 vs. 1.4, P=.01). Multifollicular growth was observed in 35.1% in the CC group and 54.8% in the FSH group (P=.01). The OPR per cycle was 9.6 and 15.6% for CC and rFSH groups, respectively (P=.31). Conclusions: Recombinant FSH is superior to CC for enabling multifollicular development in OS/IUI cycles of unexplained and male subfertile couples. Although this finding did not lead to a statistically significant superiority of rFSH in terms of clinical outcomes, the presence of relative increase by 62.5% in OPR with rFSH may be regarded as a clinically significant trend. Springer-Verlag, 2011 Clomiphene citrate nationallicence Intrauterine insemination nationallicence Male factor nationallicence Recombinant FSH nationallicence Unexplained infertility nationallicence Berker Bulent Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut Kahraman Korhan Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut Taskin Salih Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut Sukur Yavuz Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut Sonmezer Murat Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut Atabekoglu Cem Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1561-1566 0932-0067 284:6<1561 2011 284 404 https://doi.org/10.1007/s00404-011-1997-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1997-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berker Bulent Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Kahraman Korhan Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Taskin Salih Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Sukur Yavuz Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Sonmezer Murat Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Atabekoglu Cem Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1561-1566 0932-0067 284:6<1561 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer