caa a22 4500 445309709 CHVBK 20180317142625.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1854-5 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1854-5 Diagnostic performance of urgent referrals for suspected gynaecological malignancies [Elektronische Daten] [Nikolaos Burbos, Patrick Musonda, Barnaby Rufford] Purpose: The objective of this study was to investigate the outcome of the urgent referrals with suspected gynaecological malignancy. Methods: Retrospective analysis of the data of the urgent referrals for suspected gynaecological cancers over a 12-month period at a gynaecological oncology cancer centre in the UK. Results: A total of 233 patients (70.61%) were referred with suspected endometrial pathology, 59 patients (17.88%) with suspected ovarian, 25 patients (7.58%) with suspected cervical and 13 patients (3.94%) with suspected vulval malignancy. The positive predictive value of referrals for diagnosing endometrial, ovarian, cervical and vulval malignancy was 11.6, 23.7, 12.0 and 15.4%, respectively. Amongst the indications for referral for suspected endometrial cancer, presence of postmenopausal vaginal bleeding had the higher odds for cancer (odds=0.13; 95% CI 0.08-0.21). The odds for cancer for women referred with a pelvic mass was 0.17 (95% CI, 0.07-0.42) and for women referred with abdominal bloating was 0.66 (95% CI, 0.18-2.36). All the cases of malignancy were diagnosed in women referred with suspicious appearance of the cervix on clinical examination. The odds for cancer was 0.50 if the indication for referral was vulval itching. The majority of cases of gynaecological cancers during the study period were diagnosed following routine referrals. Conclusion: The overall predictive value of two-week wait referrals for suspected gynaecological malignancies is low. Refinement of the current referral guidelines is required with particular emphasis in the premenopausal women where the diagnostic performance of the urgent referrals is significantly poorer. Springer-Verlag, 2011 Urgent referral nationallicence Gynaecological cancer nationallicence Clinical indication nationallicence Burbos Nikolaos Department of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital NHS Foundation Trust, Colney Lane, NR4 7UY, Norwich, UK aut Musonda Patrick School of Medicine, Health Policy & Practice, University of East Anglia, NR4 7TJ, Norwich, UK aut Rufford Barnaby Department of Obstetrics and Gynaecology, Ipswich General Hospital, Heath Road, IP4 5PD, Ipswich, UK aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1495-1500 0932-0067 284:6<1495 2011 284 404 https://doi.org/10.1007/s00404-011-1854-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1854-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burbos Nikolaos Department of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital NHS Foundation Trust, Colney Lane, NR4 7UY, Norwich, UK aut NATIONALLICENCE 700 1- Musonda Patrick School of Medicine, Health Policy & Practice, University of East Anglia, NR4 7TJ, Norwich, UK aut NATIONALLICENCE 700 1- Rufford Barnaby Department of Obstetrics and Gynaecology, Ipswich General Hospital, Heath Road, IP4 5PD, Ipswich, UK aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1495-1500 0932-0067 284:6<1495 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer