caa a22 4500 445309725 CHVBK 20180317142625.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1870-5 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1870-5 Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity [Elektronische Daten] [Yun Wang, Tom Tanbo, Liv Ellingsen, Thomas Åbyholm, Tore Henriksen] Purpose: To investigate the effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme preterm deliveries. Methods: Retrospective study of deliveries in a Norwegian tertiary teaching hospital. All women with live births at 24+0- 27+6 weeks of gestation between 2004 and 2007 were included. Major morbidity is defined as intraventricular haemorrhage grade 3-4, periventricular leukomalacia, bronchopulmonary dysplasia or necrotizing enterocolitis. Pregestational maternal, obstetric and perinatal variables were initially compared for mortality and survival with major morbidity at 24-h, 7- or 28-day postpartum/discharge in univariate analysis. Then, a multivariate analysis was conducted in order to determine independent factors associated with mortality and survival with major morbidity. Results: A total of 109 babies were delivered alive in 92 women, representing 1.6% of total births. The survival rates were 93.6, 84.4 and 80.7%, with a prevalence of major morbidity among survivors of 40.4, 32.1 and 39.4% at 24-h, 7- and 30-day postpartum/discharge, respectively. After adjustment using multiple logistic regression, only a 5-min Apgar score ≤3 and babies with at least one major morbidity had significantly independent effects on neonatal survival. Multiple pregnancy and gestational age <26weeks were the only two independent risk factors for survival with major morbidity. Conclusions: Neonatal survival was significantly predicted by a 5-min Apgar score and neonatal morbidity, independent of pregestational maternal disease, obstetric complications, method of delivery, gestational age and birth weight in extreme preterm deliveries. The excess morbidity rate was confined among multiples and babies who were delivered before 26weeks of gestation. The Author(s), 2011 Extreme prematurity nationallicence Survival nationallicence Morbidity nationallicence Wang Yun Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut Tanbo Tom Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut Ellingsen Liv Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut Åbyholm Thomas Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut Henriksen Tore Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1381-1387 0932-0067 284:6<1381 2011 284 404 https://doi.org/10.1007/s00404-011-1870-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1870-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Yun Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut NATIONALLICENCE 700 1- Tanbo Tom Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut NATIONALLICENCE 700 1- Ellingsen Liv Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut NATIONALLICENCE 700 1- Åbyholm Thomas Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut NATIONALLICENCE 700 1- Henriksen Tore Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0023, Oslo, Norway aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1381-1387 0932-0067 284:6<1381 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer