caa a22 4500 445309733 CHVBK 20180317142625.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1873-2 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1873-2 Neonatal outcome of IVF singletons versus naturally conceived in women aged 35years and over [Elektronische Daten] [Vlatka Tomic, Jozo Tomic] Purpose: To compare the delivery and neonatal outcome of IVF singleton pregnancies with those conceived spontaneously in primiparous women ≥35years of age. Methods: Data were collected by the hospital's obstetrics and pediatric staff at the time of examination, hospitalization, delivery and discharge. A total of 283 women with in vitro fertilization (IVF) singleton deliveries were matched according to ethnicity, age, gravidity, smoking habits, body mass index, weight gain in pregnancy, site and time of delivery with consecutive 283 women conceived spontaneously. The outcome measures were mode of delivery, birth weight, preterm birth and perinatal mortality. Results: Cesarean delivery rate was more common in IVF pregnancies (39.9% vs. 25.1%; p<0.001). Preterm delivery rate, specifically of spontaneous onset was significantly higher in IVF group (18.7%) than in spontaneous conception group (10.3%; p<0.008). No difference was found in birth weight records (SGA, VLBW, LBW and LGA) or perinatal mortality rate. However, average gestational birth weight was lower among infants conceived after IVF (3,050±587g vs. 3,130±524g; p<0.05). Conclusions: Singleton IVF pregnancies in primiparous women ≥35years of age have increased perinatal risk associated with higher rates of cesarean section, preterm births and infants of lower average birth weight. Nevertheless, pregnancy and delivery complications, number of infants with low or very low birth weight, small or large birth weight for appropriate gestation did not differ from those of the spontaneous conceptions. Springer-Verlag, 2011 Advanced maternal age nationallicence In vitro fertilization nationallicence Mode of delivery nationallicence Neonatal outcome nationallicence Tomic Vlatka Department of Human Reproduction, University Hospital Center "Sisters of Mercy”, Vinogradska 29, 10 000, Zagreb, Croatia aut Tomic Jozo Department of Human Reproduction, University Hospital Center "Sisters of Mercy”, Vinogradska 29, 10 000, Zagreb, Croatia aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1411-1416 0932-0067 284:6<1411 2011 284 404 https://doi.org/10.1007/s00404-011-1873-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1873-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomic Vlatka Department of Human Reproduction, University Hospital Center "Sisters of Mercy”, Vinogradska 29, 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Tomic Jozo Department of Human Reproduction, University Hospital Center "Sisters of Mercy”, Vinogradska 29, 10 000, Zagreb, Croatia aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1411-1416 0932-0067 284:6<1411 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer