caa a22 4500 445309857 CHVBK 20180317142625.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00404-011-1857-2 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1857-2 Effective of metronidazole to bacterial flora in vagina and the impact of microbes on live birth rate during intracytoplasmic sperm injection (ICSI) [Elektronische Daten] [Samy Selim, Sahar El Alfy, Mohamed Aziz, Hussein Mohamed, Amin Alasbahi] Purpose: The aim of this study was to investigate the impact of bacterial vaginal flora on life-birth rate during ICSI and influence of metronidazole as antibiotic treatment course before ICSI. Method: We enrolled 71 women who were undergoing ICSI. At embryo transfer (ET), all of the women had quantitative vaginal culture, ET catheter-tip culture, and vaginal Gram stain scored for bacterial vaginosis. Results: The overall live birth rate (LBR) was 36.6% (26/71), and the rate of early pregnancy loss was 13% (4/30). In women with bacterial vaginosis, intermediate flora and normal flora, the conception rates were 35% (9/26), 42% (14/33) and 58% (7/12), respectively (p=0.06 for trend). Metronidazole effect to bacterial flora in vaginal. The predominant species isolated from the tip of the embryo transfer catheter in negative pregnancy was Staphylococcus epidermidis (7 vs. 15.2%), and Streptococcus viridians (11 vs. 24%). Conclusions: Woman with bacterial vaginosis and with a decreased vaginal concentration of hydrogen peroxide-producing lactobacilli may have decreased conception rates and increased rates of failed pregnancy. A larger prospective treatment trial designed to evaluate the impact on ICSI outcomes of optimizing the vaginal flora prior to ICSI may be warranted. Springer-Verlag, 2011 Infection nationallicence ICSI-ET nationallicence Metronidazole nationallicence Antimicrobial resistance nationallicence Transfer catheter nationallicence Selim Samy Microbiology Section, Botany Department, Faculty of Science, Suez Canal University, P.O. 41522, Ismailia, Egypt aut El Alfy Sahar Microbiology Section, Botany Department, Faculty of Science, Suez Canal University, P.O. 41522, Ismailia, Egypt aut Aziz Mohamed Microbiology Section, Botany Department, Faculty of Science, Suez Canal University, P.O. 41522, Ismailia, Egypt aut Mohamed Hussein IVF unit, Ismailia General Hospital, Ismailia, Egypt aut Alasbahi Amin Gomohory Hospital, Ministry of Health, Sana'a, Yemen aut Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1449-1453 0932-0067 284:6<1449 2011 284 404 https://doi.org/10.1007/s00404-011-1857-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1857-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Selim Samy Microbiology Section, Botany Department, Faculty of Science, Suez Canal University, P.O. 41522, Ismailia, Egypt aut NATIONALLICENCE 700 1- El Alfy Sahar Microbiology Section, Botany Department, Faculty of Science, Suez Canal University, P.O. 41522, Ismailia, Egypt aut NATIONALLICENCE 700 1- Aziz Mohamed Microbiology Section, Botany Department, Faculty of Science, Suez Canal University, P.O. 41522, Ismailia, Egypt aut NATIONALLICENCE 700 1- Mohamed Hussein IVF unit, Ismailia General Hospital, Ismailia, Egypt aut NATIONALLICENCE 700 1- Alasbahi Amin Gomohory Hospital, Ministry of Health, Sana'a, Yemen aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/6(2011-12-01), 1449-1453 0932-0067 284:6<1449 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer