caa a22 4500 445309873 CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-010-1736-2 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1736-2 Serum concentrations of CA-125 in normal and preeclamptic pregnancies [Elektronische Daten] [Mustafa Ozat, Mine Kanat-Pektas, Okan Yenicesu, Tayfun Gungor, Nuri Danisman, Leyla Mollamahmutoglu] Aim: The present prospective study aims to investigate the serum concentrations of CA-125 in normal and preeclamptic pregnancies and thus to specify the clinical utility of this biochemical marker in prediction, diagnosis and follow up of preeclampsia. Methods: The present study reviews a total of 242 women with singleton pregnancy. These participants were categorized into three groups: control (n=100), mild preeclampsia (n=78) and severe preeclampsia (n=64). The three study groups were statistically similar in aspects of maternal age, gestational age and body mass index. Results: Serum CA-125 concentrations were found to correlate positively with systolic blood pressure (r=0.345, p=0.001), diastolic blood pressure (r=0.379, p=0.001), platelet count (r=0.368, p=0.001), serum levels of uric acid (r=0.415, p=0.001) and urine concentrations of protein (r=0.357, p=0.001). On the other hand, CA-125 levels correlated negatively with estimated fetal weight (r=−0.451, p=0.001) and birthweight (r=−0.363, p=0.001). When the cut-off point for serum CA-125 concentrations was accepted as 50IU/ml, the sensitivity and specificity of this biochemical marker were, respectively, 93.7 and 88.0% for the detection of preeclamptic pregnancies. On the other hand, positive and negative predictive values for CA-125 were computed as 91.7 and 90.7%, respectively ( χ 2=30,184, p=0.001). Conclusion: The present study suggests that CA-125 is a biochemical marker which reflects the severity of the underlying inflammatory process in preeclampsia. Since it is much more available and relatively less expensive, it seems to be a promising test for screening preeclampsia. In accordance, the present study suggests 50IU/ml as a cut-off point for CA-125 in screening preeclampsia. Springer-Verlag, 2010 CA-125 nationallicence Concentration nationallicence Preeclampsia nationallicence Pregnancy nationallicence Ozat Mustafa Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut Kanat-Pektas Mine Department of Perinatology, Etlik Ihtisas Research and Education Hospital, Yunus Emre Mah. Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut Yenicesu Okan Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut Gungor Tayfun Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut Danisman Nuri Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut Mollamahmutoglu Leyla Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 607-612 0932-0067 284:3<607 2011 284 404 https://doi.org/10.1007/s00404-010-1736-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1736-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ozat Mustafa Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Kanat-Pektas Mine Department of Perinatology, Etlik Ihtisas Research and Education Hospital, Yunus Emre Mah. Dereboyu Sok. No: 71/2 Yenimahalle, 06170, Ankara, Turkey aut NATIONALLICENCE 700 1- Yenicesu Okan Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Gungor Tayfun Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Danisman Nuri Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Mollamahmutoglu Leyla Department of Perinatology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 607-612 0932-0067 284:3<607 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer