caa a22 4500 445309911 CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-011-1943-5 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1943-5 Neoadjuvant chemotherapy with paclitaxel plus platinum for invasive cervical cancer in pregnancy: two case report and literature review [Elektronische Daten] [Jing Li, Li-juan Wang, Bing-zhong Zhang, Yong-pai Peng, Zhong-qiu Lin] Background: Cervical cancer (including carcinoma in situ) is the most common malignancy during pregnancy. Neoadjuvant chemotherapy (NACT) with paclitaxel plus cisplatin has been used in patients with cervical cancer successfully, but experience of its prenatal treatment is limited. Case report: We report two pregnant women with locally advanced cervical cancer. They were treated with cisplatin plus paclitaxel NACT until fetal pulmonary maturity was achieved, and then accepted cesarean section followed by radical hysterectomy. To minimize the chemo-resistant/radio-resistant tumor cell clones and increase the potencies of NACT, we modified the dose of the chemotherapeutic agents and the treatment interval using cisplatin (50mg/m2) and paclitaxel (75mg/m2) every 2weeks. Evaluation for clinical response to chemotherapy displayed a partial and complete response, respectively. Both patients had not had any evidence of recurrence for 21 and 13months. Their children did not have any evidence of malformations and showed normal development at 21 and 13months of follow-up, respectively. Conclusion: Neoadjuvant chemotherapy with paclitaxel plus cisplatin appears to be feasible and safe for pregnant patients with invasive cervical cancer and infants. Springer-Verlag, 2011 Carcinoma of uterine cervix nationallicence Pregnancy nationallicence Platinum nationallicence Taxane nationallicence Li Jing Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut Wang Li-juan Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut Zhang Bing-zhong Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut Peng Yong-pai Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut Lin Zhong-qiu Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 779-783 0932-0067 284:3<779 2011 284 404 https://doi.org/10.1007/s00404-011-1943-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1943-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Jing Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Wang Li-juan Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Zhang Bing-zhong Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Peng Yong-pai Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Lin Zhong-qiu Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, West Yangjiang Road, 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 779-783 0932-0067 284:3<779 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer