caa a22 4500 445309962 CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-010-1674-z doi (NATIONALLICENCE)springer-10.1007/s00404-010-1674-z Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug [Elektronische Daten] [Suchaya Luewan, Rathasart Mahathep, Theera Tongsong] Objective: To determine hypotensive effect of nifedipine in the treatment of preterm labor. Methods: A descriptive analytic study was conducted on pregnant women treated with nifedipine as tocolytic drug for preterm labor. Maternal blood pressure before and at 15, 30, 45 and 60min after administration of nifedipine was evaluated and analyzed. Hypotension was defined as a decrease in systolic or diastolic blood pressure of 15mmHg or more. Results: A total of 157 pregnant women met the inclusion criteria. The mean systolic and diastolic blood pressure before treatment was 109.4 and 72.5mmHg, respectively. The blood pressure following treatment with nifedipine was significantly decreased both systolic and diastolic blood pressure (p<0.05) at 30, 45 and 60min. Of 157 patients, 28 (17.8%) and 27 (17.2%) had systolic and diastolic hypotension, respectively. Of the patients with decreased blood pressure, the mean decrease of systolic and diastolic blood pressure was 16.3 and 14.5mmHg, respectively. Conclusion: Nifedipine was associated with a minimal but significant decrease in blood pressure. 17% of cases have hypotension. However, hypotension secondary to nifedipine was not associated with significant clinical symptoms, suggesting that nifedipine is relatively safe in terms of hypotensive effect. Springer-Verlag, 2010 Maternal hypotension nationallicence Nifedipine nationallicence Preterm labor nationallicence Luewan Suchaya Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut Mahathep Rathasart Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut Tongsong Theera Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 527-530 0932-0067 284:3<527 2011 284 404 https://doi.org/10.1007/s00404-010-1674-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1674-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luewan Suchaya Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut NATIONALLICENCE 700 1- Mahathep Rathasart Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut NATIONALLICENCE 700 1- Tongsong Theera Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 527-530 0932-0067 284:3<527 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer