caa a22 4500 445309970 CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-010-1573-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1573-3 C-reactive protein and hormones but not IL-6 are associated to body mass index in first trimester of pregnancy [Elektronische Daten] [Gilberto Kac, Juliana dos Santos Vaz, Michael Schlüssel, Anibal Moura] Objective: To investigate if body mass index (BMI) is related to inflammatory markers and hormones in early pregnancy. Methods: A prospective study with 190 pregnant women evaluated at 10weeks when leptin, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Median and inter-quartile values of hormones and inflammatory markers are presented according to BMI quintiles. Spearman correlations and Kruskal-Wallis analysis of variance were implemented followed by Mann-Whitney post hoc pair-wise tests. Results: Leptin (P<0.001), insulin (P=0.005), HOMA-IR (P=0.015), and CRP (P=0.026) assumed higher and significantly median values as BMI quintiles increases, but no differences were observed for IL-6 (P=0.859). Pair-wise comparisons among quintiles (Q) of BMI were significant for leptin (Q1×Q3, Q1×Q4, Q1×Q5, Q2×Q4, Q2×Q5, Q3×Q5), insulin (Q1×Q5, Q2×Q5, Q3×Q5, Q4×Q5) and for CRP (Q1×Q4, Q1×Q5, Q2×Q5). Spearman correlation coefficients between BMI showed significant results for leptin (r s=0.58, P<0.001), insulin (r s=0.19, P=0.018), HOMA-IR (r s=0.22, P=0.007), CRP (r s=0.26, P<0.001), but not for IL-6 (r s=−0.06, P=0.526). Median (mg/L) values of CRP were higher in overweight (35.26) than in normal weight women (21.28, P=0.051). Conclusions: The present investigation provides evidences on the positive relationship between BMI, leptin, insulin, HOMA-IR and CRP in early pregnancy. CRP but not IL-6 demonstrated a strong relation with overweight in pregnant women, as early as the tenth week. Springer-Verlag, 2010 Pregnancy nationallicence Obesity nationallicence Inflammation nationallicence Body mass index nationallicence Hormones nationallicence Kac Gilberto Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil aut dos Santos Vaz Juliana Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil aut Schlüssel Michael Nutritional Epidemiology Observatory, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Avenida Brigadeiro Trompowsky, s/nº, CCS, Bloco J, 2º andar, sala 29, Cidade Universitária, Ilha do Fundão, 21941-590, Rio de Janeiro, RJ, Brazil aut Moura Anibal Department of Physiology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 567-573 0932-0067 284:3<567 2011 284 404 https://doi.org/10.1007/s00404-010-1573-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1573-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kac Gilberto Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- dos Santos Vaz Juliana Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- Schlüssel Michael Nutritional Epidemiology Observatory, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Avenida Brigadeiro Trompowsky, s/nº, CCS, Bloco J, 2º andar, sala 29, Cidade Universitária, Ilha do Fundão, 21941-590, Rio de Janeiro, RJ, Brazil aut NATIONALLICENCE 700 1- Moura Anibal Department of Physiology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 567-573 0932-0067 284:3<567 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer